Results 91 to 100 of about 83,600 (312)

Long-Term Effects of Botulinum Toxin Complex Type A Injection on Mechano-and Metabo-Sensitive Afferent Fibers Originating from Gastrocnemius Muscle [PDF]

, 2015
International audienceThe aim of the present study was to investigate long term effects of motor denervation by botulinum toxin complex type A (BoNT/A) from Clostridium Botulinum, on the afferent fibers originating from the gastrocnemius muscle of rats ...
Caron, Guillaume, Decherchi, Patrick, Marqueste, Tanguy   +2 more
core   +5 more sources

Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman, Mikkel C. Vinding, Panagiota Tsitsi, Per Svenningsson, Josefine Waldthaler, Daniel Lundqvist   +5 more
wiley   +1 more source

Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.

PLoS ONE, 2014
Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types.
Nir Dover, Jason R Barash, Julianne N Burke, Karen K Hill, John C Detter, Stephen S Arnon   +5 more
doaj   +1 more source

Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach

Movement Disorders, EarlyView.
ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan, Shichun Peng, Phoebe G. Spetsieris, David Eidelberg, Yilong Ma   +4 more
wiley   +1 more source

Comparison of botulinum neurotoxin type A formulations in Asia

Clinical, Cosmetic and Investigational Dermatology, 2018
Results All protein-based therapeutics, such as botulinum neurotoxin type A (BoNT/A), are potentially immunogenic and can lead to anaphylaxis, autoimmunity, or diminished or complete absence of therapeutic efficacy, especially if administered repeatedly.
J. Frevert, K. Ahn, M. Park, O. Sunga
semanticscholar   +1 more source

Lysozyme gene treatment in testosterone induced benign prostate hyperplasia rat model and comparasion of its’ effectiveness with botulinum toxin injection

International Brazilian Journal of Urology
Objectives: To compare the effects and histopathological changes of botulinum neurotoxin type A and lysozyme gene injections into prostate tissue within a testosterone induced benign prostate hyperplasia rat model.
Osman Ergün, Pinar Aslan Koşar, İbrahim Onaran, Hakan Darici, Alim Koşar   +4 more
doaj   +1 more source

Recombinant production of bacterial toxins and their derivatives in the methylotrophic yeast Pichia pastoris. [PDF]

, 2005
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Ellar, David J, Gurkan, Cemal
core   +2 more sources

Botulinum toxin for the treatment of lower limb cramp pain in patients with Amyotrophic Lateral Sclerosis [PDF]

, 2020
Background: Muscle cramps and pain associated with them can be seen in patients with amyotrophic lateral sclerosis (ALS) and are known to reduce the quality of life. Pharmacological treatment may not benefit all patients in treating these cramps.
Govindarajan, Raghav, Mehta, Tejas, Sommers, Richard   +2 more
core   +2 more sources

EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder

Movement Disorders, EarlyView.
ABSTRACT Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document the first case of CMMs spontaneously occurring in Weimaraner dogs and to identify the underlying genetic ...
Cleo Schwarz, Florian Bartenschlager, Olivia Kershaw, Judith Braun, Julien Guevar, Vidhya Jagannathan, Jörg T. Epplen, Wencke Reineking, Wolfgang Baumgärtner, Kailash P. Bhatia, Achim D. Gruber, Tosso Leeb   +11 more
wiley   +1 more source

Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance

Frontiers in Bioengineering and Biotechnology, 2018
Botulism outbreak due to consumption of food contaminated with botulinum neurotoxins (BoNTs) is a public health emergency. The threat of bioterrorism through deliberate distribution in food sources and/or aerosolization of BoNTs raises global public ...
Nagarajan Thirunavukkarasu, Eric A. Johnson, S. Pillai, David R. Hodge, L. Stanker, T. Wentz, Balram Singh, K. Venkateswaran, P. McNutt, M. Adler, Eric Brown, T. Hammack, D. Burr, S. Sharma   +13 more
semanticscholar   +1 more source