Results 81 to 90 of about 116,934 (269)

Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum

BMC Genomics, 2009
Background Proteolytic Clostridium botulinum is the causative agent of botulism, a severe neuroparalytic illness. Given the severity of botulism, surprisingly little is known of the population structure, biology, phylogeny or evolution of C.
Twine Susan M, Mason David R, Paul Catherine J, Carter Andrew T, Alston Mark J, Logan Susan M, Austin John W, Peck Michael W   +7 more
doaj   +1 more source

Muscle volume alterations after first botulinum neurotoxin A treatment in children with cerebral palsy: a 6‐month prospective cohort study

Developmental Medicine & Child Neurology, 2018
This study aimed to track alterations in muscle volume for 6 months in children with cerebral palsy (CP) after the first exposure to botulinum neurotoxin A (BoNT‐A), a commonly used focal spasticity treatment.
C. Alexander, C. Elliott, J. Valentine, K. Stannage, N. Bear, C. Donnelly, P. Shipman, S. Reid   +7 more
semanticscholar   +1 more source

How Can We Personalize the Delivery of Onabotulinumtoxin‐A for Patients With Neurogenic Lower Urinary Tract Dysfunction?

Neurourology and Urodynamics, EarlyView.
ABSTRACT Background & Aims Neurogenic lower urinary tract dysfunction (NLUTD) can produce bothersome urinary symptoms, impact quality of life, and in some cases, lead to deterioration of upper urinary tract function. Intradetrusor injection of onabotulinumtoxin‐A (BoNT‐A) is approved for NLUTD in patients who have an inadequate response to or ...
Shirley L. Wang, William I. Jaffe, Ariana L. Smith   +2 more
wiley   +1 more source

Histopathological changes of the buccal mucosa and skin after botulinum neurotoxin intramuscular injection in rats (immunohistochemical study)

BMC Oral Health
Background A surplus of clinical studies focused mainly on the clinical impacts of botulinum neurotoxin type A disregarding the histopathological changes stemming from its injection.
Gihan S. Hassan, Basant H. Abouzaid, Reda G. Saleh   +2 more
doaj   +1 more source

Botulinum neurotoxin: Not only in Dermatology - Expanding Therapeutic Horizons Across Medical Specialties

Journal of Education, Health and Sport
Background. Botulinum neurotoxin (BTX) is commonly associated with cosmetic applications; however, its therapeutic relevance extends far beyond aesthetic medicine.
Klaudia Kurzątkowska, Dominika Marszałek, Aleksandra Ocimek, Michalina Czudowska, Magdalena Zawadzka, Emilia Borychowska, Karolina Gwóźdź, Zofia Aneta Mierzejewska, Marta Drozdowska, Aleksandra Natalia Bytros   +9 more
doaj   +1 more source

Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury–Induced Neuropathic Pain Models

Journal of Pharmacological Sciences, 2012
Botulinum toxin type A is a unique candidate for inhibition of pain transmission. In the present study we attempted to see the beneficial actions of A2 neurotoxin (NTX), an active subunit of botulinum toxin type A.
Lin Ma, Jun Nagai, Yuki Sekino, Yoshitaka Goto, Shinji Nakahira, Hiroshi Ueda   +5 more
doaj   +1 more source

Systemic adverse events after botulinum neurotoxin A injections in children with cerebral palsy

Developmental Medicine & Child Neurology, 2018
To identify factors that increase the likelihood of systemic adverse events after botulinum neurotoxin A (BoNT‐A) injections in children with cerebral palsy (CP).
S. Paget, Caitlyn M Swinney, K. Burton, K. Bau, S. O'Flaherty   +4 more
semanticscholar   +1 more source

Pseudo‐Dystonic Gait in a Preschool Child: Foot Posturing Contralateral to a Cuboid Fracture

Movement Disorders Clinical Practice, EarlyView.
Allison J. Chirigos, Donald L. Gilbert, Barbara E. Hallinan, Jes Marchbank, Alberto J. Espay   +4 more
wiley   +1 more source

Passive shoulder mobility and active shoulder external rotation recovery in upper‐trunk brachial plexus birth injuries after nerve repair

Developmental Medicine &Child Neurology, EarlyView.
This was a retrospective cohort study of 322 patients with upper trunk brachial plexus birth injury following nerve surgery of C5 and/or C6. We found that a substantial gap remained between passive and active shoulder external rotation in adduction, indicating that passive mobility is not the limiting factor in active external rotation recovery ...
Eva T. E. Ulmann, Jochem Nagels, Willem Pondaag, Martijn J. A. Malessy   +3 more
wiley   +1 more source

Structure of dual receptor binding to botulinum neurotoxin B [PDF]

, 2014
Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors.
Peng, Lisheng, Dong, Min, Stenmark, Pål, Berntsson, Ronnie P-A   +3 more
core   +1 more source