Results 91 to 100 of about 20,701 (223)

Long-Term Effects of Botulinum Toxin Complex Type A Injection on Mechano-and Metabo-Sensitive Afferent Fibers Originating from Gastrocnemius Muscle [PDF]

, 2015
International audienceThe aim of the present study was to investigate long term effects of motor denervation by botulinum toxin complex type A (BoNT/A) from Clostridium Botulinum, on the afferent fibers originating from the gastrocnemius muscle of rats ...
Caron, Guillaume, Decherchi, Patrick, Marqueste, Tanguy   +2 more
core   +6 more sources

Guideline of guidelines: Peyronie's disease

BJU International, Volume 137, Issue 5, Page 770-782, May 2026.
Objective To compare major Peyronie's disease (PD) guidelines, highlight key similarities and differences among panel recommendations, and identify areas requiring further research. Methods An extensive review was conducted to analyse and compare diagnostic and treatment recommendations from publicly available guidelines published by the American ...
Francesco Chierigo, Giuseppe Fallara, Marco Tozzi, Andrea Salonia, Matteo Ferro, Hussain M Alnajjar, Asif Muneer, Karl H. Pang   +7 more
wiley   +1 more source

An Ultrasensitive Gold Nanoparticle-based Lateral Flow Test for the Detection of Active Botulinum Neurotoxin Type A

Nanoscale Research Letters, 2017
Botulism is a severe and potentially lethal paralytic disease caused by several botulinum neurotoxin-producing Clostridia spp. In China, the majority of the cases caused by botulism were from less-developed rural areas.
Jing Liu, Shan Gao, Lin Kang, Bin Ji, Wenwen Xin, Jingjing Kang, Ping Li, Jie Gao, Hanbin Wang, Jinglin Wang, Hao Yang   +10 more
doaj   +1 more source

Long-term efficacy of botulinum toxin A for treatment of blepharospasm,hemifacial spasm, and spastic entropion: a multicentre study using two drug-dose escalation indexes [PDF]

, 2010
PURPOSE: To investigate the long-term effectiveness and safety of botulinum neurotoxin A (BoNT-A) treatment in patients with blepharospasm (BEB), hemifacial spasm (HFS), and entropion (EN) and to use for the first time two modified indexes, 'botulin ...
A Berardelli, A Casuccio, A Cetinkaya, A Neetens, A Wang, AB Scott, AB Scott, AL Pang, B Wabbels, BR Frueh, C Kenney, D Dressler, D Truong, DA Cohen, DH Steel, DM Simpson, DM Yoshimura, EM Helveston, Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group, F Di Pace, F Grandas, F Micheli, G Cossu, G Defazio, G Defazio, G Raimondi, GT Drummond, J Carruthers, J Jankovic, J Jankovic, J Reimer, JA Mauriello, JA Mauriello, JD Porter, JD Taylor, JJ Dutton, JJ Dutton, JJ Dutton, JJ Dutton, JL Vitek, JR Ainsworth, JR Clarke, JS Elston, JS Elston, M Cillino, M Flanders, M Hallett, M Snir, MZ Atassi, N Guépratte, P Calace, P Greene, P Roggenkämper, PF Engstrom, RG Auger, RL Anderson, RL Levy, RM Siatkowski, RS Gonnering, S Cillino, S Damiani, S Jitpimolmard, S Mercadante, S Ochudlo, SS Lowe, Subcommittee of the American Academy of Neurology, T Vogt, W Huang   +67 more
core   +1 more source

Fall experiences of ambulatory children and adults with cerebral palsy: A qualitative study using thematic content analysis

Developmental Medicine &Child Neurology, Volume 68, Issue 5, Page 673-680, May 2026.
Abstract Aim To qualitatively assess the causes, adaptations, and psychosocial impact of falls, and solutions for safer environments, as shared by individuals diagnosed with cerebral palsy (CP). Method Ambulatory adults with CP (n = 165; age median [interquartile range], range: 30 years [25–50], 18–76 years); 101 females, 59 males, five non‐binary/not ...
Marissa Esterley, Linda E. Krach, Kari Pederson, Sandy Callen Tierney, Nathan G. Wandersee, Elizabeth R. Boyer, on behalf of The Cerebral Palsy Research Network   +6 more
wiley   +1 more source

Botulinum neurotoxins

, 2023
Botulinum neurotoxins (BoNTs) are the most potent toxins known to man, with less than 1 μg of pure toxin being enough to kill an adult man. Despite the high toxicity, BoNTs are widely used in cosmetics and in medicine for the treatment of an increasing number of medical conditions.
openaire   +1 more source

Synaptotagmin Binding to Botulinum Neurotoxins

Biochemistry, 2019
Botulinum neurotoxins (BoNTs) are exceptionally toxic proteins that cause paralysis but are also extensively used as treatment for various medical conditions. Most BoNTs bind two receptors on neuronal cells, namely, a ganglioside and a protein receptor.
Markel Martínez-Carranza, Pilar Blasco, Robert Gustafsson, Min Dong, Ronnie Per-Arne Berntsson, Göran Widmalm, Pål Stenmark   +6 more
openaire   +4 more sources

Emerging Opportunities for Serotypes of Botulinum Neurotoxins

Toxins, 2012
Background: Two decades ago, botulinum neurotoxin (BoNT) type A was introduced to the commercial market. Subsequently, the toxin was approved by the FDA to address several neurological syndromes, involving muscle, nerve, and gland hyperactivity.
John Tapia-Núñez, Michael S. Okun, Aparna Wagle Shukla, Ramon L. Rodriguez, J. Glenn Morris, Zhongxing Peng Chen   +5 more
doaj   +1 more source

Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]

, 1994
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Binz, T., Dayanithi, G., Gratzl, Manfred, Höhne-Zell, B., Niemann, H., Stecher, B., Weller, U., Yamasaki, S.   +7 more
core   +1 more source

Biosecurity Threat Posed by Botulinum Toxin

Toxins, 2019
The deliberate release of biological agents with terrorist or criminal intent continues to pose concerns in the current geopolitical situation. Therefore, attention is still needed to ensure preparedness against the potential use of pathogens as ...
Orlando Cenciarelli, Paul William Riley, Agoritsa Baka   +2 more
doaj   +1 more source