Results 91 to 100 of about 116,934 (269)

Transynaptic Action of Botulinum Neurotoxin Type A at Central Cholinergic Boutons

Journal of Neuroscience, 2018
Botulinum neurotoxin Type A (BoNT/A) is an effective treatment for several movement disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) at the neuromuscular junction, thus blocking ...
M. Caleo, M. Spinelli, Francesca Colosimo, I. Matak, O. Rossetto, Z. Lacković, L. Restani   +6 more
semanticscholar   +1 more source

Botulinum neurotoxin A, blinding, and bias [PDF]

Developmental Medicine & Child Neurology, 2019
This article is commented on by Day on page 159 of this issue.
Tandy Hastings‐Ison, Kerr Graham
openaire   +3 more sources

Pain trajectories in children and adolescents with cerebral palsy: A longitudinal population‐based register study

Developmental Medicine &Child Neurology, EarlyView.
Four pain trajectories were identified in a population‐based register study of 4887 children and adolescents with cerebral palsy: (1) increasing trend, low probability of experiencing pain (20.28%), (2) increasing trend, high probability of experiencing pain (30.30%), (3) decreasing trend (26.85%), and (4) consistently high probability of experiencing ...
May Phyu Sin, Johan Jarl, David L. Roth, Ann I. Alriksson‐Schmidt   +3 more
wiley   +1 more source

Medial gastrocnemius volume and echo‐intensity after botulinum neurotoxin A interventions in children with spastic cerebral palsy

Developmental Medicine & Child Neurology, 2018
This cross‐sectional investigation evaluated whether recurrent botulinum neurotoxin A (BoNT‐A) interventions to the medial gastrocnemius have an influence on muscle morphology, beyond Gross Motor Function Classification System (GMFCS) level.
S. Schless, F. Cenni, L. Bar-On, B. Hanssen, B. Kalkman, T. O'Brien, E. Aertbeliën, A. Van Campenhout, G. Molenaers, K. Desloovere   +9 more
semanticscholar   +1 more source

Asymmetric Upper Limb Dysfunction Demonstrated at the Bedside: A Phenomenology Video

Movement Disorders Clinical Practice, EarlyView.
Gero Lueg, Martin Fruth, Nina Rosa Neuendorff, Rainer Wirth, Markus A. Hobert   +4 more
wiley   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Pallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)

Neurological Research and Practice, 2019
Background Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia.
Thorsten M. Odorfer, Uwe Malzahn, Cordula Matthies, Peter U. Heuschmann, Jens Volkmann   +4 more
doaj   +1 more source

Early Cervical and Orofacial Variable Dystonia in Levodopa‐Naïve PRKN Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Amy Gallagher, Aine Redmond, John McKinley, John Inocentes, Diana A Olszewska, Conor Fearon, Tim Lynch   +6 more
wiley   +1 more source

Muscle morphology and intramuscular fat after treatment‐as‐usual including botulinum neurotoxin A injections in children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Normalized muscle volume remained unchanged in all evaluated muscles after the 12‐month treatment‐as‐usual in children with cerebral palsy. Higher intramuscular fat fraction was observed in the medial gastrocnemius, suggesting concurrent intramuscular fat infiltration.
Zhongzheng Wang, Antea Destro, Alexandra Åhblom, Sven Petersson, Ferdinand Von Walden, Eva Pontén, Cecilia Lidbeck, Ruoli Wang   +7 more
wiley   +1 more source

Protein Domain Analysis of C. botulinum Type A Neurotoxin and Its Relationship with Other Botulinum Serotypes

, 2009
Botulinum neurotoxins (BoNTs) are highly potent poisons produced by seven serotypes of Clostridium botulinum. The mechanism of neurotoxin action is a multistep process which leads to the cleavage of one of three different SNARE proteins essential for ...
Shashi K. Sharma, Uma Basavanna, Hem D. Shukla   +2 more
core   +1 more source