Results 91 to 100 of about 46,671 (223)

Toxicon [PDF]

Botulinum neurotoxin-producing species of Clostridium are highly diverse. Clostridium botulinum could represent at least four different species of Clostridium. In addition, strains that do not produce botulinum neurotoxin are closely related to toxigenic

core  

Emerging Opportunities for Serotypes of Botulinum Neurotoxins

Toxins, 2012
Background: Two decades ago, botulinum neurotoxin (BoNT) type A was introduced to the commercial market. Subsequently, the toxin was approved by the FDA to address several neurological syndromes, involving muscle, nerve, and gland hyperactivity.
John Tapia-Núñez, Michael S. Okun, Aparna Wagle Shukla, Ramon L. Rodriguez, J. Glenn Morris, Zhongxing Peng Chen   +5 more
doaj   +1 more source

Synaptotagmin Binding to Botulinum Neurotoxins

Biochemistry, 2019
Botulinum neurotoxins (BoNTs) are exceptionally toxic proteins that cause paralysis but are also extensively used as treatment for various medical conditions. Most BoNTs bind two receptors on neuronal cells, namely, a ganglioside and a protein receptor.
Markel Martínez-Carranza, Pilar Blasco, Robert Gustafsson, Min Dong, Ronnie Per-Arne Berntsson, Göran Widmalm, Pål Stenmark   +6 more
openaire   +4 more sources

Neutralizing antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports

, 2013
Sebastian Torres,1 Mark Hamilton,2 Elena Sanches,4 Polina Starovatova,3 Elena Gubanova,3 Tatiana Reshetnikova51Di Stefano Velona Clinic, Catania, Italy; 2Hamilton Face Clinic, Dublin, Ireland; 3Preventive Medicine Clinic "Vallex M", Moscow ...
Sanches E, Starovatova P, Reshetnikova T, Gubanova E, Torres S, Hamilton M   +5 more
core  

Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications

Toxins
This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules.
Aisha Zhantleuova, Charlotte Leese, Anna P. Andreou, Altynay Karimova, Guy Carpenter, Bazbek Davletov   +5 more
doaj   +1 more source

Biosecurity Threat Posed by Botulinum Toxin

Toxins, 2019
The deliberate release of biological agents with terrorist or criminal intent continues to pose concerns in the current geopolitical situation. Therefore, attention is still needed to ensure preparedness against the potential use of pathogens as ...
Orlando Cenciarelli, Paul William Riley, Agoritsa Baka   +2 more
doaj   +1 more source

Complete continence after botulinum neurotoxin type A injections for refractory idiopathic detrusor overactivity incontinence: patient-reported outcome at 4 weeks [PDF]

, 2010
Objective improvement following intradetrusor injections of botulinum neurotoxin type A (BoNTA) is well documented. Although patient-related outcome measures are highly recommended for monitoring overactive bladder symptoms, no study before has dealt ...
Panicker, Jalesh, Khan, Shahid, Kessler, Thomas M, Dasgupta, Prokar, Fowler, Clare J, Elneil, Sohier, Roosen, Alexander, Gonzales, Gwen, Jalesh Panicker, Thomas M. Kessler, Clare J. Fowler, Sohier Elneil, Shahid Khan, Prokar Dasgupta, Alexander Roosen, Gwen Gonzales   +15 more
core   +1 more source

Effect of Botulinum Neurotoxin Type A in Induced Benign Prostatic Hyperplasia Male Rats

, 2021
Aim of the study: To explain the mechanism of action and compare the effect of botulinum neurotoxin A with standard treatment (Alfuzosin and dutasteride). Methodology: Five groups each of them composed of 10 rats.
Majid, Ghazi Faisal
core   +1 more source

Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

Journal of Pain Research, 2011
Yiangos Yiangou1 Uma Anand1,2, William R. Otto2, Marco Sinisi3, Michael Fox3, Rolfe Birch3 Keith A. Foster4, Gaurav Mukerji1,5, Ayesha Akbar1,6, Sanjiv K.
Yiangou Y, An, U, Otto WR, Sinisi M, Fox M, Birch R, Foster KA, Mukerji G, Akbar A, Agarwal SK, An, P   +12 more
doaj  

Type E Botulinum Neurotoxin-Producing Clostridium butyricum Strains Are Aerotolerant during Vegetative Growth

mSystems, 2019
Clostridium butyricum, the type species of the genus Clostridium, is considered an obligate anaerobe, yet it has been shown to grow in the presence of oxygen. C. butyricum strains atypically producing the botulinum neurotoxin type E are the leading cause
Serena Camerini, Lucia Marcocci, Lara Picarazzi, Egidio Iorio, Irene Ruspantini, Paola Pietrangeli, Marco Crescenzi, Giovanna Franciosa   +7 more
doaj   +1 more source