Results 71 to 80 of about 116,934 (269)

CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C.

PLoS ONE, 2015
Botulinum neurotoxins produced by Clostridium botulinum cause flaccid paralysis by inhibiting neurotransmitter release at peripheral nerve terminals. Previously, we found that neurons derived from the murine P19 embryonal carcinoma cell line exhibited ...
Kentaro Tsukamoto, Chikako Ozeki, Tomoko Kohda, Takao Tsuji   +3 more
doaj   +1 more source

Identification of a novel botulinum neurotoxin gene cluster in Enterococcus

FEBS Letters, 2018
The deadly neurotoxins of Clostridium botulinum (BoNTs) comprise eight serotypes (A–G; X). The neurotoxin gene cluster encoding BoNT and its accessory proteins includes an operon containing an ntnh gene upstream of the boNT gene.
J. Brunt, A. T. Carter, S. Stringer, M. Peck   +3 more
semanticscholar   +1 more source

Efficacy of IncobotulinumtoxinA (BoNT‐A) Injections in Upper Limb Task‐Specific and Position‐Dependent Tremors

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Task‐specific tremors (TST) and position‐dependent tremors (PDT) are rare isolated focal tremors that impair fine motor control with few effective treatment options. Although botulinum neurotoxin (BoNT) is effective in other tremor syndromes, its evidence in these tremor subtypes remains limited.
Elizabeth K. Boyd, Shangge Jiang, Runjie Bill Shi, Philippe Rizek   +3 more
wiley   +1 more source

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Lnk, H., Gratzl, Manfred   +5 more
core   +1 more source

The Role of Botulinum Neurotoxin A in the Conservative Treatment of Fractures: An Experimental Study on Rats

The Scientific World Journal
This paper explores the role of botulinum neurotoxin in aiding fracture recovery through temporary muscle paralysis. Specifically, it investigates the effects of botulinum neurotoxin-induced paralysis of the sternocleidomastoid muscle on clavicle ...
Themistoklis Vampertzis, Christina Barmpagianni, Chryssa Bekiari, Georgia D. Brellou, Ioannis A. Zervos, Eleftherios Tsiridis, Nikiforos Galanis   +6 more
doaj   +1 more source

Aptamer-based electrochemical biosensor for Botulinum neurotoxin [PDF]

, 2009
We have developed an aptamer-based electrochemical sensor for detection of Botulinum neurotoxin, where steric hindrance is applied to achieve specific signal amplification via conformational change of the aptamer.
Fang Wei, Wei, Fang, Ho, Chih-Ming, Chih-Ming Ho   +3 more
core   +1 more source

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta, Carolina Gorodetsky, Todd M. Herrington, Angela L. Hewitt, Daniel E. Lumsden, Jennifer O'Malley, Terence Sanger   +6 more
wiley   +1 more source

Uso da toxina botulínica no controle do bruxismo [PDF]

, 2014
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.A toxina botulínica é uma substância produzida pela bactéria Clostridium botulinum, e o seu uso oferece ao cirurgião dentista uma nova alternativa para ...
Francescon, Ariane
core  

Applications, impacts and consequences of botulinum toxin usage in medicine

Journal of Education, Health and Sport
Introduction Botulinum toxin is a neurotoxin produced by the gram-positive bacteria Clostridium botulinum. Botulinum toxin has found great interest in the field of aesthetic medicine, but it has many other applications in other areas of medicine.  
Weronika Kiełt, Julia Kozłowska, Gabriela Broniec, Barbara Wajdowicz, Aleksandra Kudła, Rozalia Czapiewska, Aleksandra Dziewulska, Aleksandra Wróbel, Laura Pacek, Klaudia Kowalska   +9 more
doaj   +1 more source

Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism

Movement Disorders, EarlyView.
Abstract Background Bilateral pallidal deep brain stimulation (GPi‐DBS) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi‐DBS.
Clément Desjardins, Cécilia Bonnet, Elena Moro, David Grabli, Valérie Fraix, Marie‐Laure Welter, Laurent Vercueil, Soledad Navarro, Carine Karachi, Thibaud Charrier, Sylvie Raoul, Mathilde Guibourd de Luzinais, Emmanuel Cuny, Stéphan Chabardes, Pierre Burbaud, Dominique Guehl, Pascal Derkinderen, Marie Vidailhet, on behalf of the French SPIDY Study Group, Olivier Detante, Valérie Fraix, Pierre Pollak, Laurent Vercueil, Yves Agid, David Grabli, Jean‐Luc Houeto, Valérie Mesnage, Marie Vidailhet, Marie‐Laure Welter, Pierre Césaro, Luc Defebvre, Alain Destée, Pierre Krystkowiak, Alim‐Louis Benabid, Stephan Chabardes, Adnan Koudsie, Philippe Cornu, Soledad Navarro, Serge Blond, Gustavo Touzet, Abdelhamid Benazzouz, Bernard Pidoux, François Cassim, Sylvie Grand, Jean‐François Le Bas, Didier Dormont, Jean‐Pierre Pruvo, Christine Delmaire, Claire Ardouin, Bernard Pillon, Valérie Hahn‐Barma, Kathy Dujardin.   +51 more
wiley   +1 more source