Results 71 to 80 of about 46,671 (223)

Zebrafish Sensitivity to Botulinum Neurotoxins [PDF]

Toxins, 2016
Botulinum neurotoxins (BoNT) are the most potent known toxins. The mouse LD50 assay is the gold standard for testing BoNT potency, but is not sensitive enough to detect the extremely low levels of neurotoxin that may be present in the serum of sensitive animal species that are showing the effects of BoNT toxicity, such as channel catfish affected by ...
Kamalakar Chatla, Patricia Gaunt, Lora Petrie-Hanson, Lorelei Ford, Larry Hanson   +4 more
openaire   +3 more sources

Combined dorsal and ventral rhizotomy in non‐ambulatory individuals with mixed spastic bilateral cerebral palsy: A prospective registry analysis

Developmental Medicine &Child Neurology, EarlyView.
This is the largest North American study of combined dorsal/ventral rhizotomy in non‐ambulatory, bilateral, mixed spastic–dyskinetic cerebral palsy (33 patients). Combined rhizotomy was safe, improved dystonia (Barry–Albright Dystonia Scale), spasticity (modified Ashworth scale), quality of life (Caregiver Priorities and Child Health Index of Life with
Adam C. Glaser, Joon Hyeok Choi, Kristin Buxton, Nahyun Kim, Juliana Mariani, Benjamin J. Shore, Weston T. Northam   +6 more
wiley   +1 more source

Structure of dual receptor binding to botulinum neurotoxin B [PDF]

, 2014
Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors.
Peng, Lisheng, Dong, Min, Stenmark, Pål, Berntsson, Ronnie P-A   +3 more
core   +1 more source

Pallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)

Neurological Research and Practice, 2019
Background Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia.
Thorsten M. Odorfer, Uwe Malzahn, Cordula Matthies, Peter U. Heuschmann, Jens Volkmann   +4 more
doaj   +1 more source

Transcriptome‐Based Identification of ZZEF1 and ENTPD5 as Candidate Genes for Dystonia

Movement Disorders, EarlyView.
Alexandra Rudnik, Mirja Thomsen, Vicente A. Yépez, Ai Huey Tan, Frauke Hinrichs, Sebastian Loens, Shen‐Yang Lim, Yi Wen Tay, Thomas Musacchio, Sören Franzenburg, Tobias Bäumer, Marius Möller, Hauke Busch, Christine Klein, Norbert Brüggemann, Katja Lohmann   +15 more
wiley   +1 more source

Muscle tone and pain in children with spastic cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To investigate associations between muscle tone measured using the Modified Ashworth Scale (MAS) and pain in children with spastic cerebral palsy (CP). Method Children (aged 0–17 years; mean age 10 years 2 months) in the Norwegian Quality and Surveillance Registry for Cerebral Palsy with physical therapy assessments between 2018 and 2021 ...
Olav Aga Kildal, Sandra Julsen Hollung, Keson Jaioun, Guro L. Andersen   +3 more
wiley   +1 more source

Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B Protease

, 2016
Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B ...
Michael A. Hanson (2213152), Daniel H. Rich (1972099), Raymond C. Stevens (270962), Chanokporn Sukonpan (2984046), Thorsten K. Oost (2503873)   +4 more
core   +1 more source

Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study [PDF]

, 2009
Aim: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. Methods: Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport (R)). The primary endpoint was reduction in
Toelle, Thomas, Straube, Andreas, Ceballos-Baumann, Andres, Volker Pfaffenrath, Petri, Susanne, Pfaffenrath, Volker, Susanne Petri, Thomas Tölle, Ulrich Stefenelli, Andres Ceballos-Baumann, Stefenelli, Ulrich, Andreas Straube, Petri, S;Tölle, T;Straube, A;Pfaffenrath, V;Stefenelli, U;Ceballos-Baumann, A, Petri, Susanne;Tölle, Thomas;Straube, Andreas;Pfaffenrath, Volker;Stefenelli, Ulrich;Ceballos-Baumann, Andres   +13 more
core   +1 more source

Treating chronic anal fissure with botulinum neurotoxin [PDF]

, 2004
Recent reports confirm that the management of chronic anal fissure has undergone extensive re-evaluation during the past few years. This rejuvenation of interest is attributable to the application of neurochemical treatment, which has contributed to the ...
Brisinda D., Brisinda G., Cadeddu F.
core   +2 more sources

Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.

PLoS ONE, 2014
Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types.
Nir Dover, Jason R Barash, Julianne N Burke, Karen K Hill, John C Detter, Stephen S Arnon   +5 more
doaj   +1 more source