Results 101 to 110 of about 83,600 (312)

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]

, 2008
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh, Dan Li, James Keller, Michael Adler, Peng Zhang, Prabhati Ray, Radharaman Ray   +6 more
core   +1 more source

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]

, 2020
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng, Lam, Kwok-Ho, McNutt, Patrick M, Ondeck, Celinia, Perry, Kay, Shoemaker, Charles B, Tremblay, Jacqueline M, Vazquez-Cintron, Edwin, Webb, Robert P   +8 more
core  

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Lnk, H., Nordmann, J. J., Weller, U.   +5 more
core   +1 more source

Stroke Mimicking Thalamotomy in Primary Familial Brain Calcification

Movement Disorders Clinical Practice, EarlyView.
Jaakko Kungshamn, Emma Ottela, Olli Likitalo, Anna Brück, Juho Joutsa   +4 more
wiley   +1 more source

Tremor Asymmetry and the Development of Bilateral Phase‐Specific Deep Brain Stimulation for Postural Tremor

Movement Disorders, EarlyView.
Abstract Background Tremor phase‐locked deep brain stimulation (DBS) has been shown to modulate symptom severity in postural tremor, including essential and dystonic tremor, with less energy than existing systems. Previous studies focused on unilateral stimulation; it remains unknown how tremor asymmetry interacts with stimulation in the context of ...
Shenghong He, Alceste Deli, Timothy O. West, Fernando R. Plazas, Alek Pogosyan, Christoph Wiest, Laura Wehmeyer, Fahd Baig, Francesca Morgante, Pablo Andrade, Michael G. Hart, James J. FitzGerald, Veerle Visser‐Vandewalle, Erlick A. Pereira, Alexander L. Green, Huiling Tan, Hayriye Cagnan   +16 more
wiley   +1 more source

Botulinum neurotoxin–encoding plasmids can be conjugatively transferred to diverse clostridial strains

Scientific Reports, 2018
Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids.
Erin M. Nawrocki, M. Bradshaw, Eric A. Johnson   +2 more
semanticscholar   +1 more source

Therapeutic Uses and Efficacy of Botulinum Toxin in Orofacial Medicine: A Dental Perspective

Toxins
Botulinum neurotoxin (BoNT) is the exotoxin of Clostridium botulinum, a Gram-positive, spore-forming bacterium [...]
Kazuya Yoshida, Merete Bakke
doaj   +1 more source

Pallidal neurostimulation versus botulinum toxin injections in the treatment of cervical dystonia: protocol of a randomized, sham-controlled trial (StimTox-CD)

Neurological Research and Practice, 2019
Background Selective peripheral denervation via botulinum neurotoxin injections into dystonic muscles is the first-line treatment for cervical dystonia.
Thorsten M. Odorfer, Uwe Malzahn, Cordula Matthies, Peter U. Heuschmann, Jens Volkmann   +4 more
doaj   +1 more source

Opsoclonus‐Myoclonus: Not Always Paraneoplastic

Movement Disorders Clinical Practice, EarlyView.
Fernanda Lustosa Cabral Gomez, Luiz José Malta Gaia Ferreira Júnior, Sofia Mônaco Gama, Fabiano Moulin de Moraes, Flávio Moura Rezende Filho   +4 more
wiley   +1 more source

Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi‐Cohort Study

Movement Disorders, EarlyView.
ABSTRACT Background Resilience factors are crucial in the progression of neurodegenerative diseases. However, it remains unclear whether a genetic predisposition to cognitive reserve influences clinical heterogeneity in the prognosis of Parkinson's disease (PD).
Young Eun Huh, Beomjin Jang, Sang‐Hyuk Jung, Dokyoon Kim, Towfique Raj, Hong‐Hee Won   +5 more
wiley   +1 more source