Results 131 to 140 of about 116,934 (269)

A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin.

Journal of Infectious Diseases, 2016
Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin (BoNT) on nerve cells. There are 7 known serotypes (A-G) of BoNT and up to 40 genetic variants.
S. Maslanka, C. Lúquez, Janet K. Dykes, W. Tepp, Christina L. Pier, S. Pellett, Brian H. Raphael, Suzanne R. Kalb, J. Barr, Agam K. Rao, E. Johnson   +10 more
semanticscholar   +1 more source

Xenobiotic transfer of onabotulinumtoxinA using an ex vivo human placental perfusion model: A pilot study

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Objective OnabotulinumtoxinA is an effective preventive therapy for chronic migraine; however, data on fetal exposure during pregnancy are limited. We aimed to evaluate transplacental transfer of onabotulinumtoxinA using an ex vivo human placental perfusion model.
Alexandra Loza, Ali Lotfi, Richard Wagner, Alexander Aksenov, Andrea Shields   +4 more
wiley   +1 more source

Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

Journal of Pain Research, 2011
Yiangos Yiangou1 Uma Anand1,2, William R. Otto2, Marco Sinisi3, Michael Fox3, Rolfe Birch3 Keith A. Foster4, Gaurav Mukerji1,5, Ayesha Akbar1,6, Sanjiv K.
Yiangou Y, An, U, Otto WR, Sinisi M, Fox M, Birch R, Foster KA, Mukerji G, Akbar A, Agarwal SK, An, P   +12 more
doaj  

Type E Botulinum Neurotoxin-Producing Clostridium butyricum Strains Are Aerotolerant during Vegetative Growth

mSystems, 2019
Clostridium butyricum, the type species of the genus Clostridium, is considered an obligate anaerobe, yet it has been shown to grow in the presence of oxygen. C. butyricum strains atypically producing the botulinum neurotoxin type E are the leading cause
Serena Camerini, Lucia Marcocci, Lara Picarazzi, Egidio Iorio, Irene Ruspantini, Paola Pietrangeli, Marco Crescenzi, Giovanna Franciosa   +7 more
doaj   +1 more source

A Cell Line for Detection of Botulinum Neurotoxin Type B

Frontiers in Pharmacology, 2017
Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.
A. Rust, Ciara G. Doran, Rosalyn Hart, T. Binz, P. Stickings, D. Sesardic, Andrew A. Peden, B. Davletov   +7 more
semanticscholar   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source

An Investigation of Immunogenicity of Chitosan-Based Botulinum Neurotoxin E Binding Domain Recombinant Candidate Vaccine via Mucosal Route

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Botulism syndrome is caused by serotypes A-G of neurotoxins of Clostridium genus. Neurotoxin binding domain is an appropriate vaccine candidate due to its immunogenic activity.
Mohammad Javad Bagheripour, Firouz Ebrahim, Abbas Hajizadeh, Shahram Nazarian, Jamil Zargan, Jamal Rashidiani   +5 more
doaj  

Electrochemical impedance spectroscopy biosensor for detection of active botulinum neurotoxin

Sensing and Bio-Sensing Research, 2014
The standard method for the detection of botulinum neurotoxin is currently the mouse bioassay which is considered to be the most reliable method for the detection of the active form of this toxin.
Jennifer Halliwell, Alison C. Savage, Nicholas Buckley, Christopher Gwenin   +3 more
doaj   +1 more source

From Heritage to Innovation: A Review of the Safety and Production of Aminopeptide Seasonings

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Aminopeptide seasonings, produced through proteolytic fermentation or enzymatic hydrolysis, represent a global family of ingredients with a high concentration of umami‐active free amino acids and umami‐ or kokumi‐active peptides derived from protein‐rich substrates.
José María Martín‐Miguélez, José de la Rosa Morón, Nabila Rodríguez Valerón, Alberto Alía, Josué Delgado   +4 more
wiley   +1 more source

Neutralizing antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports

, 2013
Sebastian Torres,1 Mark Hamilton,2 Elena Sanches,4 Polina Starovatova,3 Elena Gubanova,3 Tatiana Reshetnikova51Di Stefano Velona Clinic, Catania, Italy; 2Hamilton Face Clinic, Dublin, Ireland; 3Preventive Medicine Clinic "Vallex M", Moscow ...
Sanches E, Starovatova P, Reshetnikova T, Gubanova E, Torres S, Hamilton M   +5 more
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