Results 141 to 150 of about 116,934 (269)

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

Nature Structural &Molecular Biology, 2016
Botulinum neurotoxin serotype A1 (BoNT/A1), a licensed drug widely used for medical and cosmetic applications, exerts its action by invading motoneurons.
G. Yao, Sicai Zhang, S. Mahrhold, K. Lam, D. Stern, K. Bagramyan, K. Perry, M. Kalkum, A. Rummel, M. Dong, Rongsheng Jin   +10 more
semanticscholar   +1 more source

Protocol and Demographics of the RELY-CD Study: Assessing Long-Term Clinical Response to Botulinum Neurotoxin in Cervical Dystonia

Toxins
The RELY-CD study investigated the long-term clinical response to botulinum neurotoxin type A in cervical dystonia within a multicenter, real-world setting.
Benjamin Waeschle, John-Ih Lee, Tristan Kölsche, Robin Jansen, Marta Banach, Stanislaw Ochudlo, Małgorzata Tyślerowicz, Piotr Sobolewski, Sara Sánchez Valiente, Eva López-Valdés, Pablo Mir, Silvia Jesús, Elena Ojeda-Lepe, Ewa Papuć, Pilar Sánchez Alonso, Gabriel Salazar, Georg Comes, Holger Stark, Philipp Albrecht   +18 more
doaj   +1 more source

Longer‐term imaging of muscle quality after routine BoNT‐A care in cerebral palsy: Beyond muscle volume

Developmental Medicine &Child Neurology, EarlyView.
Sian A. Williams
wiley   +1 more source

Structure of dual receptor binding to botulinum neurotoxin B

, 2013
Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors.
Dong, M., Stenmark, P., Peng, Lisheng, Dong, Min, Stenmark, Pål,, Berntsson, R.P. A., Berntsson, Ronnie P. A.,, Peng, L.   +7 more
core   +1 more source

Clean intermittent self-catheterization after botulinum neurotoxin type A injections: short-term effect on quality of life

, 2009
OBJECTIVE: To investigate the hypothesis that the need for clean intermittent self-catheterization after botulinum neurotoxin type A injections is outweighed by the efficacy of this treatment, so that clean intermittent self-catheterization is not a ...
Panicker, Jalesh, Khan, Shahid, Kessler, Thomas M, Fowler, Clare J, Elneil, Sohier, Roosen, Alexander   +5 more
core  

Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors

, 2016
Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite ...
Nicholas T. Salzameda (2268529), Peter Šilhár (1893691), Kateřina Čapková (2313226), Joseph T. Barbieri (460376), Mark S. Hixon (240454), Kim D. Janda (163029)   +5 more
core   +1 more source

In the human urothelium and suburothelium, intradetrusor botulinum neurotoxin type A does not induce apoptosis: preliminary results [PDF]

, 2010
Intradetrusor injections of botulinum neurotoxin type A (BoNTA) are emerging as the preferred second-line treatment for neurogenic and idiopathic overactive bladder (OAB).
Khan, Shahid, Kessler, Thomas M, Fowler, Clare J, Brandner, Sebastian, Elneil, Sohier, Roosen, Alexander, Panicker, Jalesh N   +6 more
core   +1 more source

Botulinum neurotoxin formulations: overcoming the confusion [Corrigendum]

, 2018
Samizadeh S, De Boulle K. Clin Cosmet Investig Dermatol. 2018;11:273–287.On page 273, Introduction section, line 5, the sentence “The human nervous system is susceptible to BoNT-A, B, C, E, F, and G and unaffected by D.1,4–6&rdquo ...
De Boulle K, Samizadeh S
core  

Toxicon [PDF]

Botulinum neurotoxin-producing species of Clostridium are highly diverse. Clostridium botulinum could represent at least four different species of Clostridium. In addition, strains that do not produce botulinum neurotoxin are closely related to toxigenic

core  

Structural studies of botulinum neurotoxin progenitor complexes and tetanus neurotoxin

, 2014
My project has focused on understanding the structural organization of the clostridial neurotoxins, botulinum and tetanus, that are the causative agents of the neuroparalytic diseases botulism and tetanus.
Benefield, Desirée Allyn
core