Results 141 to 150 of about 83,600 (312)

SNARE based peptide linking as an efficient strategy to retarget botulinum neurotoxin’s enzymatic domain to specific neurons using diverse neuropeptides as targeting domains [PDF]

, 2011
Many disease states are caused by miss-regulated neurotransmission. A small fraction of these diseases can currently be treated with botulinum neurotoxin type A (BoNT/A).
,, Arsenault, Jason, Davletov, Bazbek, Ferrari, Enrico, Gu, Chungjing, O'Brien, John, Ruiperez, Violeta   +6 more
core  

Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system. [PDF]

, 1979
Nobutaka Hirokawa, Masaru Kitamura
openalex   +1 more source

Effectiveness and safety of abobotulinumtoxinA in pediatric lower limb spasticity: A phase IV, prospective, observational, multicenter study

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To assess the longitudinal attainment of patient‐centered, function‐related Goal Attainment Scaling Total (GAS T)‐score after repeated abobotulinumtoxinA (AboBoNT‐A) injections over a period of up to 30 months and up to 10 cycles. Method In this prospective observational study, the investigators' clinical practices recruited patients aged ...
Mark E. Gormley, Edward Dabrowski, Mauricio R. Delgado, Ann Tilton, Asare Christian, Sarah Helen Evans, Anne‐Sophie Grandoulier, Jumaah Goldberg   +7 more
wiley   +1 more source

Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

Journal of Pain Research, 2011
Yiangos Yiangou1 Uma Anand1,2, William R. Otto2, Marco Sinisi3, Michael Fox3, Rolfe Birch3 Keith A. Foster4, Gaurav Mukerji1,5, Ayesha Akbar1,6, Sanjiv K.
Yiangou Y, An, U, Otto WR, Sinisi M, Fox M, Birch R, Foster KA, Mukerji G, Akbar A, Agarwal SK, An, P   +12 more
doaj  

The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins

Toxins, 2010
The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively ...
Frank J. Lebeda, Regina Z. Cer, Uma Mudunuri, Robert Stephens, Bal Ram Singh, Michael Adler   +5 more
doaj   +1 more source

Molecular forms of neurotoxins in proteolytic Clostridium botulinum type B cultures [PDF]

, 1976
Bibhuti R. DasGupta, Hitoshi Sugiyama
openalex   +1 more source

Equine botulism

Equine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source

Differentiating Botulinum Neurotoxin-Producing Clostridia with a Simple, Multiplex PCR Assay

Applied and Environmental Microbiology, 2017
Diverse members of the genus Clostridium produce botulinum neurotoxins (BoNTs), which cause a flaccid paralysis known as botulism. While multiple species of clostridia produce BoNTs, the majority of human botulism cases have been attributed to ...
C. H. Williamson, Adam J. Vazquez, K. Hill, Theresa J. Smith, Roxanne Nottingham, N. E. Stone, C. Sobek, J. Cocking, R. Fernández, P. Caballero, Owen P Leiser, P. Keim, J. Sahl   +12 more
semanticscholar   +1 more source

Dual functions of SNAP25 in mouse taste buds

The Journal of Physiology, EarlyView.
Abstract figure legend Conditional knockout of Snap25 in taste cells leads to a marked reduction in the number of sour‐responsive Type III cells in both fungiform and circumvallete papillae of mice. In behavioral assays, Snap25/Trpv1 double knockout mice display increased licking to sour tastants, suggesting impaired aversive responses.
Kengo Horie, Kuanyu Wang, Hai Huang, Keiko Yasumatsu, Yuzo Ninomiya, Yoshihiro Mitoh, Ryusuke Yoshida   +6 more
wiley   +1 more source

An Investigation of Immunogenicity of Chitosan-Based Botulinum Neurotoxin E Binding Domain Recombinant Candidate Vaccine via Mucosal Route

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Botulism syndrome is caused by serotypes A-G of neurotoxins of Clostridium genus. Neurotoxin binding domain is an appropriate vaccine candidate due to its immunogenic activity.
Mohammad Javad Bagheripour, Firouz Ebrahim, Abbas Hajizadeh, Shahram Nazarian, Jamil Zargan, Jamal Rashidiani   +5 more
doaj