Results 21 to 30 of about 59,082 (309)

Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.

PLoS ONE, 2014
Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types.
Nir Dover, Jason R Barash, Julianne N Burke, Karen K Hill, John C Detter, Stephen S Arnon   +5 more
doaj   +1 more source

Tetanus: Pathophysiology, Treatment, and the Possibility of Using Botulinum Toxin against Tetanus-Induced Rigidity and Spasms

Toxins, 2013
Tetanus toxin, the product of Clostridium tetani, is the cause of tetanus symptoms. Tetanus toxin is taken up into terminals of lower motor neurons and transported axonally to the spinal cord and/or brainstem. Here the toxin moves trans-synaptically into
Bjørnar Hassel
doaj   +1 more source

Diagnostic nerve block in prediction of outcome of botulinum toxin treatment for spastic equinovarus foot after stroke: A retrospective observational study

Journal of Rehabilitation Medicine, 2020
Objective: To evaluate the role of diagnostic nerve block in predicting the outcome of subsequent botulinum toxin type A treatment for spastic equinovarus foot due to chronic stroke. Design: Retrospective observational study.
Alessandro Picelli, Elisa Battistuzzi, Mirko Filippetti, Angela Modenese, Marialuisa Gandolfi, Daniele Munari, Nicola Smania   +6 more
doaj   +1 more source

Botulinum toxin A for the Treatment of Overactive Bladder

Toxins, 2016
The standard treatment for overactive bladder starts with patient education and behavior therapies, followed by antimuscarinic agents. For patients with urgency urinary incontinence refractory to antimuscarinic therapy, currently both American Urological
Po-Fan Hsieh, Hung-Chieh Chiu, Kuan-Chieh Chen, Chao-Hsiang Chang, Eric Chieh-Lung Chou   +4 more
doaj   +1 more source

Diffusion of Botulinum Toxins

Tremor and Other Hyperkinetic Movements, 2012
Background: It is generally agreed that diffusion of botulinum toxin occurs, but the extent of the spread and its clinical importance are disputed. Many factors have been suggested to play a role but which have the most clinical relevance is a subject of much discussion.
Brodsky, Matthew A., Swope, David M., Grimes, David   +2 more
openaire   +5 more sources

Isolated head tremor

Неврология, нейропсихиатрия, психосоматика
Isolated head tremor (IHT) is a pathological condition characterized by tremor of the head without dystonic posturing or tremor in other parts of the body. In the past, head tremor was commonly referred to as essential tremor because it is very common in
Z. A. Zalyalova, M. M. Ermakova, Z. G. Khayatova   +2 more
doaj   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Intra-sphincteric botulinum toxin in the management of functional biliary pain

Endoscopy International Open, 2022
Background and study aims The management of functional biliary-type pain remains a clinical challenge. Intra sphincteric botulinum toxin putatively exerts an anti-spasmodic and anti-nociceptive effect.
Shyam Menon, Andrew Holt, Adam D. Farmer
doaj   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Probabilistic Lesion Mapping to Optimize Thalamotomy Targets for Focal Hand Dystonia

Annals of Neurology, EarlyView.
Objective Focal hand dystonia (FHD) severely impairs task‐specific motor control, yet the optimal surgical target for stereotactic intervention remains uncertain. This study aimed to identify the precise thalamic lesion site associated with symptomatic improvement and to clarify its network connectivity. Methods We retrospectively analyzed 164 patients
Masahiko Nishitani, Shiro Horisawa, Konstantin Butenko, Hiroki Togo, Arun Garimella, William Drew, Melissa Chua, Esraa Shaban, Takakazu Kawamata, Takaomi Taira, Andreas Horn, Michael D. Fox, Takashi Hanakawa   +12 more
wiley   +1 more source