Results 161 to 170 of about 135,997 (338)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Botulinum toxin-A for the treatment of neuralgia: a systematic review and meta-analysis
, 2018 Fan Meng, Ke Peng, Jian-Ping Yang, Fu-Hai Ji, Fan Xia, Xiao-Wen Meng Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Aim: This meta-analysis was performed to evaluate the efficacy and safety of ...
Meng F +5 more
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Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
, 2019 Bagus Komang SatriyasaDepartment of Pharmacology, Faculty of Medicine, Udayana University, Bali, IndonesiaBackground: Botulinum toxin (Botox) consists of 7 types of neurotoxins; however, only toxins A and B are used clinically.
Satriyasa BK
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Community Dentistry and Oral Epidemiology, EarlyView.ABSTRACT Objectives The objective of this scoping review was to map existing literature on oral health and related care in individuals with Motor Neurone Disease (MND). Specifically, the review aimed to identify barriers and facilitators to maintaining oral hygiene, summarise available clinical guidelines and patient‐facing resources, and examine how ...
Mariam A. Khokhar +3 more
wiley +1 more source
Botulinum toxin A, brain and pain.
Progress in neurobiology, 2014 I. Matak, Z. Lacković
semanticscholar +1 more source
, 2009 Botulinum toxin is a neurotoxic protein produced by the bacterium Clostridium botulinum. Although botulinum toxin is the cause of the disease botulism and can be used in a terrorist attack, there are also many other uses for botulinum toxin.
Moshayev, David
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Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3
The FEBS Journal, EarlyView.Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova +6 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To assess weight loss with atogepant 60 mg once daily during long‐term treatment of chronic migraine (CM) and episodic migraine (EM) among participants previously failed by two to four classes of conventional oral preventive medications.
Dale S. Bond +9 more
wiley +1 more source