Results 11 to 20 of about 21,819 (222)

In Vivo Model of Short-Term Efficacy and Favorable Safety of Botulinum Toxin Type E Compared with Type A. [PDF]

Toxins (Basel)
Botulinum toxin suppresses neurotransmitter release, thereby inhibiting muscle contraction and inducing flaccid paralysis. Botulinum toxin type A (BoNT/A) is widely used for neuromuscular blockade but, upon repeated administration, may cause long-lasting
Nam JS, Yoon D, Kim Y, Kim SY, Kim JY, Cha Y, Seok J, Kim BJ.   +7 more
europepmc   +2 more sources

Botulinum toxin type A in treatment of chronic migraine, spasticity and bruxism

Journal of Education, Health and Sport, 2023
Introduction: Nowadays, botulinum toxin has found use in many disease entities such as chronic migraine, spasticity, bruxism and many others. Among serotypes A-E, type A is mainly used in treatment.
Klaudia Kuliga, Katarzyna Dobko, Gabriela Frącz, Agata Glac, Kinga Musz, Natalia Sejnowska, Agnieszka Socha, Agata Surowiec, Kinga Śnieżek, Anna Zając   +9 more
doaj   +1 more source

Cellular and population strategies underpinning neurotoxin production and sporulation in Clostridium botulinum type E cultures

mBio, 2023
Toxin production and sporulation are key determinants of pathogenesis in Clostridia. Clostridium botulinum produces the most potent toxin known, the botulinum neurotoxin (BoNT), which blocks neurotransmission and causes a life-threatening paralysis ...
Anna Mertaoja, Gerald Mascher, Maria B. Nowakowska, Hannu Korkeala, Adriano O. Henriques, Miia Lindstrom   +5 more
doaj   +1 more source

Development of a technique for DNA detection and identification of toxigenic strains of Clostridium botulinum types A, B, E by the Real-Time PCR method

Вестник войск РХБ защиты, 2023
Botulism is dangerous toxic infection caused by a toxin produced by the bacterium Clostridium botulinum. The mortality rate from botulism can reach 70% of all cases of illness in case of untimely initiation of treatment.
D. S. Yanov, A. V. Kuznetsovskiy, M. I. Dubrovin, A. V. Mironin, N. V. Onuchina, A. V. Filippov   +5 more
doaj   +1 more source

Double Sandwich ELISA Modified Method for the Detection of Clostridium Botulinum Type E [PDF]

Journal of Fasa University of Medical Sciences, 2013
Background & Objective: A very small amount of botulinum toxin can cause death and on the other hand, there is no cure for its poison other than antitoxin.
Mohammad Ebrahim minaei, Mojtaba Saadati
doaj   +1 more source

Analysis of a unique Clostridium botulinum strain from the Southern hemisphere producing a novel type E botulinum neurotoxin subtype

BMC Microbiology, 2012
Background Clostridium botulinum strains that produce botulinum neurotoxin type E (BoNT/E) are most commonly isolated from botulism cases, marine environments, and animals in regions of high latitude in the Northern hemisphere. A strain of C.
Raphael Brian H, Lautenschlager Matthew, Kalb Suzanne R, de Jong Laura I T, Frace Michael, Lúquez Carolina, Barr John R, Fernández Rafael A, Maslanka Susan E   +8 more
doaj   +1 more source

Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.

PLoS ONE, 2014
Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types.
Nir Dover, Jason R Barash, Julianne N Burke, Karen K Hill, John C Detter, Stephen S Arnon   +5 more
doaj   +1 more source

Different frequencies of repetitive transcranial magnetic stimulation combined with local injection of botulinum toxin type A for post-stroke lower limb spasticity: study protocol for a prospective, single-center, non-randomized, controlled clinical trial

Neural Regeneration Research, 2022
[INLINE:1] No definite consensus has currently been reached regarding the safety and efficacy of low- or high-frequency repetitive transcranial magnetic stimulation in the treatment of post-stroke muscle spasticity.
Yang Shao, Yang Yang, Yong-Xin Sun, Ai-Hua Xu   +3 more
doaj   +1 more source

Botulism outbreak in a rural Ethiopia: a case series

BMC Infectious Diseases, 2021
Background Foodborne botulism, a toxin-mediated illness caused by Clostridium botulinum, is a public health emergency. Types A, B, and E C. botulinum toxins commonly cause human disease.
Tigist Bacha, Ermias Abebaw, Ayalew Moges, Amsalu Bekele, Afework Tamiru, Ishmael Shemsedin, Dawd S. Siraj, Daddi Jima, Wondwossen Amogne   +8 more
doaj   +1 more source

Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft

Biomolecules, 2022
Botulinum neurotoxins are the deadliest microbial neurotoxins in humans, with a lethal dose of 1 ng/kg. Incidentally, these neurotoxins are also widely used for medical and cosmetic purposes.
Fodil Azzaz, Didier Hilaire, Jacques Fantini   +2 more
doaj   +1 more source