Results 11 to 20 of about 40,647 (354)

Evaluation of sweating responses in patients with systemic connective tissue disorders using the quantitative sudomotor axon reflex test

open access: yesJournal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 208-216, December 2022., 2022
We investigated 85 patients on the relationship between the axon reflex sweat volume or the reaction time and Raynaud's phenomenon, skin symptoms and patient background. Most patients did not show a decrease in sweating, but one in three patients showed less sweating in summer than in winter.
Miwa Ashida   +5 more
wiley   +1 more source

Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review

open access: yesElectrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley   +1 more source

Electrical Stimulation of Injected Muscles to Boost Botulinum Toxin Effect on Spasticity: Rationale, Systematic Review and State of the Art

open access: yesToxins, 2021
Botulinum toxin type A (BoNT-A) represents a first-line treatment for spasticity, a common disabling consequence of many neurological diseases. Electrical stimulation of motor nerve endings has been reported to boost the effect of BoNT-A. To date, a wide
Alessandro Picelli   +6 more
doaj   +1 more source

Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
Abstract Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying pathophysiology and for the development, evaluation, and translation of more effective treatments.
Shirley N. Tang   +13 more
wiley   +1 more source

rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type A prophylaxis

open access: yesFrontiers in Microbiology, 2022
Botulinum neurotoxin (BoNT) is one of the most dangerous bacterial toxins and a potential biological weapon component. BoNT mechanism of pathological action is based on inhibiting the release of neurotransmitters from nerve endings.
Artem A. Derkaev   +9 more
doaj   +1 more source

Botulinum toxin: a boon or bane in dentistry [PDF]

open access: yes, 2022
Botulinum toxin is a neurotoxin which is produced by the Clostridium botulinum bacteria. It is an anaerobic, gram-positive, spore-forming rod-shaped bacteria which is commonly found in soil, on plants, in water and in the intestinal tracts of animals ...
Goel, Sumit   +4 more
core   +2 more sources

Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy

open access: yesToxins, 2015
Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism and
Alison C. Savage   +3 more
doaj   +1 more source

The binding of botulinum neurotoxins to different peripheral neurons [PDF]

open access: yes, 2017
Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core   +1 more source

Botulinum Neurotoxins (BoNTs) and Their Biological, Pharmacological, and Toxicological Issues: A Scoping Review

open access: yesApplied Sciences, 2021
Botulinum toxins or neurotoxins (BoNTs) are the most potent neurotoxins known, and are currently extensively studied, not only for their potential lethality, but also for their possible therapeutic and cosmetic uses.
Massimo Corsalini   +10 more
doaj   +1 more source

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