Results 31 to 40 of about 40,647 (354)

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Lnk, H., Nordmann, J. J., Weller, U.   +5 more
core   +1 more source

Pharmacotherapy of Spasticity in Children With Cerebral Palsy

Journal of the Formosan Medical Association, 2011
Spasticity is a common disability in children with cerebral palsy. Pharmacological and non-pharmacological treatments, including physical therapy, occupational therapy, orthotics, rhizotomy, and orthopedic surgery, all play important roles in the ...
Chia-Ying Chung, Chia-Ling Chen, Alice May-Kuen Wong   +2 more
doaj   +1 more source

Septic shock due to Clostridium botulinum: a case report

Journal of Medical Case Reports, 2023
Background Clostridium botulinum is an anaerobic, Gram-positive, rod-shaped bacterium that forms spores and the neurotoxin botulinum. It is best known for its toxin-induced flaccid paralytic disease, which is deadly without correct treatment.
P. M. L. Zomer, M. J. A. Kamps
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Interventions to improve tolerability of local anesthetic intradetrusor Botulinum toxin injections: A systematic review

Neurourology and Urodynamics, Volume 42, Issue 1, Page 23-32, January 2023., 2023
Abstract Introduction Intradetrusor BotulinumtoxinA (BTA) injections are recommended for patients with overactive bladder (OAB) refractory to lifestyle changes and medical intervention. It is preferable to perform injections using a flexible cystoscope under local anesthetic (LA) rather than under spinal or general anesthetic owing to the associated ...
Nicholas Faure Walker, Finn Macpherson, Ali Tasleem, Tarannum Rampal   +3 more
wiley   +1 more source

Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H. [PDF]

, 2016
BackgroundOnly Clostridium botulinum strain IBCA10-7060 produces the recently described novel botulinum neurotoxin type H (BoNT/H). BoNT/H (N-terminal two-thirds most homologous to BoNT/F and C-terminal one-third most homologous to BoNT/A) requires ...
Arnon, Stephen S, Barash, Jason R, Conrad, Fraser, Fan, Yongfeng, Lou, Jianlong, Marks, James D   +5 more
core   +1 more source

AbobotulinumtoxinA is effective in patients with urinary incontinence due to neurogenic detrusor overactivity regardless of spinal cord injury or multiple sclerosis etiology: Pooled analysis of two phase III randomized studies (CONTENT1 and CONTENT2)

Neurourology and Urodynamics, Volume 42, Issue 1, Page 153-167, January 2023., 2023
Abstract Background Neurogenic detrusor overactivity incontinence (NDOI) is often inadequately managed with oral therapy. Objective To assess efficacy and safety of abobotulinumtoxinA (aboBoNT‐A; Dysport®; Ipsen Ltd.) according to etiology of NDOI. Design, Setting, and Participants Two phase III, randomized, double‐blind studies (CONTENT1 [NCT02660138]
Pierre Denys, Juan Carlos Castaño Botero, Ricardo Luis Vita Nunes, Barton Wachs, Cristiano Mendes Gomes, Grigory Krivoborodov, Le Mai Tu, Giulio Del‐Popolo, Catherine Thompson, Claire Vilain, Magali Volteau, Michael Kennelly, Dysport CONTENT program group   +12 more
wiley   +1 more source

Clinical Recovery and Circulating Botulinum Toxin Type F in Adult Patient

Emerging Infectious Diseases, 2009
A 56-year-old woman in Helena, Montana, USA, who showed clinical signs of paralysis, received antitoxins to botulinum toxins A, B, and E within 24 hours; nevertheless, symptoms progressed to complete quadriplegia. On day 8, she began moving spontaneously,
Jeremy Sobel, Tracy Dill, Christina L. Kirkpatrick, Laurel Riek, Patrick Luedtke, Todd A. Damrow   +5 more
doaj   +1 more source

Wide range applications of botulinum toxin in medicine - literature review

Journal of Education, Health and Sport, 2023
Introduction and purpose : Botulinum toxin is one of the most dangerous natural toxins. Botulinum toxin poisoning causes botulism. Botulism is a set of systemic symptoms resulting from flaccid muscle paralysis.
Aleksandra Serwik-Trandasir, Agata Kania, Malwina Gonet, Karolina Miszczyk, Karolina Włodarczyk-Cybulska, Patrycja Maj, Natalia Sergiel, Piotr Mozer, Jakub Maternia, Michal Lazar   +9 more
doaj   +1 more source

CsrA and its regulators control the time-point of ColicinE2 release in Escherichia coli [PDF]

Scientific Reports 8, 6537 (2018), 2018
The bacterial SOS response is a cellular reaction to DNA damage, that, among other actions, triggers the expression of colicin - toxic bacteriocins in Escherichia coli that are released to kill close relatives competing for resources. However, it is largely unknown, how the complex network regulating toxin expression controls the time-point of toxin ...
arxiv   +1 more source