Results 71 to 80 of about 1,407,977 (315)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of the Growth Rates and Biometric Traits in Meat Crossbred Calves

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this study was to evaluate the body weight and some biometric measurements on meat crossbred calves comparative with Romanian Black Spotted dairy calves at weaning (4 months).
Marinela Enculescu, Radu Ionel Neamt, Ioana Nicolae   +2 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Marchetti, B, Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B., Araibi, E. H.   +5 more
core   +1 more source

Effects of marker density and minor allele frequency on genomic prediction for growth traits in Chinese Simmental beef cattle

Journal of Integrative Agriculture, 2017
Genomic selection has been demonstrated as a powerful technology to revolutionize animal breeding. However, marker density and minor allele frequency can affect the predictive ability of genomic estimated breeding values (GEBVs).
Bo ZHU, Jing-jing ZHANG, Hong NIU, Long GUAN, Peng GUO, Ling-yang XU, Yan CHEN, Lu-pei ZHANG, Hui-jiang GAO, Xue GAO, Jun-ya LI   +10 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis [PDF]

, 2009
Background Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital tract and mammary gland ...
Andy Barron, Maskell, Duncan, Field, TR, Leigh, James A., Nicola Lennard, Quail, MA, Clark, L, Parkhill, J, Egan, Sharon A., Bignell, A, Bentley, Stephen D., Holden, Matthew T. G., Terence R Field, Clark, Louise, Lennard, Nicola, Philip N Ward, Whatmore, AM, Ward, Philip N., Matthew TG Holden, Dowson, Christopher G., Adrian M Whatmore, Sharon A Egan, Barrell, BG, Bart G Barrell, Whatmore, Adrian M., Barron, Andy, Holden, MTG, Kehoe, M, Egan, SA, Neil Chanter, Bentley, SD, Quail, Michael A., Alexandra Bignell, Stephen D Bentley, Chanter, Neil, Louise Clark, Leigh, JA, Barron, A, Julian Parkhill, Woodward, J, Barrell, Bart G., Woodward, John, Bignell, Alexandra, Michael A Quail, Parkhill, Julian, James A Leigh, Dowson, CG, Christopher G Dowson, Ward, PN, Chanter, N, Duncan Maskell, Maskell, D, Michael Kehoe, John Woodward, Lennard, N, Kehoe, Michael, Field, Terence R.   +56 more
core   +1 more source

Tackling Weaning Stress in Dairy Calves Using Cannabidiol Oil Supplementation—A Pilot Study

Dairy
This pilot study evaluated the effects of cannabidiol (CBD) oil supplementation on growth performance, stress biomarkers, and haematological profiles in dairy calves undergoing the weaning transition.
Marinela Enculescu, Ioana Nicolae, Dinu Gavojdian   +2 more
doaj   +1 more source

Gene expression in the digestive tissues of ruminants and their relationships with feeding and digestive processes

Animal, 2010
The gastrointestinal tract (GIT) has multiple functions including digestion, nutrient absorption, secretion of hormones and excretion of wastes. In the ruminant animal, development of this organ system is more complex than that of the monogastric animal ...
E.E. Connor, R.W. Li, R.L. Baldwin, VI, C. Li   +3 more
doaj   +1 more source