Results 81 to 90 of about 1,408,621 (315)

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis [PDF]

, 2009
Background Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital tract and mammary gland ...
Andy Barron, Maskell, Duncan, Field, TR, Leigh, James A., Nicola Lennard, Quail, MA, Clark, L, Parkhill, J, Egan, Sharon A., Bignell, A, Bentley, Stephen D., Holden, Matthew T. G., Terence R Field, Clark, Louise, Lennard, Nicola, Philip N Ward, Whatmore, AM, Ward, Philip N., Matthew TG Holden, Dowson, Christopher G., Adrian M Whatmore, Sharon A Egan, Barrell, BG, Bart G Barrell, Whatmore, Adrian M., Barron, Andy, Holden, MTG, Kehoe, M, Egan, SA, Neil Chanter, Bentley, SD, Quail, Michael A., Alexandra Bignell, Stephen D Bentley, Chanter, Neil, Louise Clark, Leigh, JA, Barron, A, Julian Parkhill, Woodward, J, Barrell, Bart G., Woodward, John, Bignell, Alexandra, Michael A Quail, Parkhill, Julian, James A Leigh, Dowson, CG, Christopher G Dowson, Ward, PN, Chanter, N, Duncan Maskell, Maskell, D, Michael Kehoe, John Woodward, Lennard, N, Kehoe, Michael, Field, Terence R.   +56 more
core   +1 more source

Tackling Weaning Stress in Dairy Calves Using Cannabidiol Oil Supplementation—A Pilot Study

Dairy
This pilot study evaluated the effects of cannabidiol (CBD) oil supplementation on growth performance, stress biomarkers, and haematological profiles in dairy calves undergoing the weaning transition.
Marinela Enculescu, Ioana Nicolae, Dinu Gavojdian   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Deriving bovine embryonic stem-like cells in defined conditions [PDF]

, 2011
The first embryonic stem ES cell line was isolated from mouse in 1981 (Evans and Kaufman 1981; Martin1981). However, ESCs are only available in rodent species.
Muhammad Alahdal, Hadil, Hadil Muhammad Alahdal   +1 more
core  

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium [PDF]

, 2012
Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression ...
Sax, Gerhard, Minten, Megan, Winter, Gerhard, Büttner, Mathias, Reichenbach, Horst-Dieter, Wolf, Eckhard, Meyer, Heinrich H. D., Bauersachs, Stefan, Reichenbach, Myriam, Spencer, Thomas E., Ulbrich, Susanne E.   +10 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Neues internationales Fleischrinderprojekt BovINE gestartet: EU fördert Entwicklung eines europaweiten Rindfleisch-Innovationsnetzes mit 2 Millionen Euro [PDF]

, 2020
Das neue transeuropäische Fleischrinderprojekt BovINE wurde heute (21. Januar) in Irland gestartet. Mit dem Projekt soll die nachhaltige Fleischrinderhaltung gefördert werden.

core  

Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania. [PDF]

, 2013
BACKGROUND: Bovine tuberculosis (bTB) is a chronic debilitating disease and is a cause of morbidity and mortality in livestock, wildlife and humans. This study estimated the prevalence and risk factors associated with bovine tuberculosis transmission in ...
Matee, Mecky I., Helden, P., Godfrey-Faussett, P, Kibiki, Gibson S, Mbugi, E. V., Esron D Karimuribo, Anita L Michel, Godfrey-Faussett, Peter, Michel, Anita L, Kendall, S, Godfrey-Faussett, P., Kazwala, R R, Mbugi, Erasto V., Julius D Keyyu, Michel, Anita Luise, Kazwala, Rudovick R, Karimuribo, E D, Kendall, Sharon, Sharon Kendall, Katale, Bugwesa Z., Mbugi, E V, Karimuribo, Esron D., Kendall, Sharon L., Katale, B. Z., Rudovick R Kazwala, Michel, A. L., van Helden, Paul, Kibiki, Gibson S., Keyyu, Julius D, Katale, Bugwesa Z, Kendall, S., Karimuribo, Esron D, Michel, A L, Michel, Anita L., Kazwala, R. R., Mecky I Matee, Kazwala, Rudovick R., Kibiki, G S, Matee, M I, Keyyu, J D, Matee, Mecky I, Mbugi, Erasto V, Matee, M., van Helden, P, Keyyu, J. D., Bugwesa Z Katale, Paul van Helden, Van Helden, Paul David, Erasto V Mbugi, Kibiki, G. S., Katale, B Z, Keyyu, Julius D., Gibson S Kibiki, Peter Godfrey-Faussett, Karimuribo, E. D.   +54 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source