Results 81 to 90 of about 1,407,977 (315)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium [PDF]

, 2012
Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression ...
Sax, Gerhard, Minten, Megan, Winter, Gerhard, Büttner, Mathias, Reichenbach, Horst-Dieter, Wolf, Eckhard, Meyer, Heinrich H. D., Bauersachs, Stefan, Reichenbach, Myriam, Spencer, Thomas E., Ulbrich, Susanne E.   +10 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Produktiver erster nationaler BovINE-Workshop am 12. November 2020: [Tagungsbericht]

, 2020
Am 12.11.2020 fand der erste nationale BovINE-Workshop als Online-Veranstaltung statt. Der Workshop war mit 33 Teilnehmern gut besucht. Neben Landwirten und Vertretern verschiedener Zuchtorganisationen nahmen auch Industrie und die Fachpresse an der ...

core  

Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania. [PDF]

, 2013
BACKGROUND: Bovine tuberculosis (bTB) is a chronic debilitating disease and is a cause of morbidity and mortality in livestock, wildlife and humans. This study estimated the prevalence and risk factors associated with bovine tuberculosis transmission in ...
Matee, Mecky I., Helden, P., Godfrey-Faussett, P, Kibiki, Gibson S, Mbugi, E. V., Esron D Karimuribo, Anita L Michel, Godfrey-Faussett, Peter, Michel, Anita L, Kendall, S, Godfrey-Faussett, P., Kazwala, R R, Mbugi, Erasto V., Julius D Keyyu, Michel, Anita Luise, Kazwala, Rudovick R, Karimuribo, E D, Kendall, Sharon, Sharon Kendall, Katale, Bugwesa Z., Mbugi, E V, Karimuribo, Esron D., Kendall, Sharon L., Katale, B. Z., Rudovick R Kazwala, Michel, A. L., van Helden, Paul, Kibiki, Gibson S., Keyyu, Julius D, Katale, Bugwesa Z, Kendall, S., Karimuribo, Esron D, Michel, A L, Michel, Anita L., Kazwala, R. R., Mecky I Matee, Kazwala, Rudovick R., Kibiki, G S, Matee, M I, Keyyu, J D, Matee, Mecky I, Mbugi, Erasto V, Matee, M., van Helden, P, Keyyu, J. D., Bugwesa Z Katale, Paul van Helden, Van Helden, Paul David, Erasto V Mbugi, Kibiki, G. S., Katale, B Z, Keyyu, Julius D., Gibson S Kibiki, Peter Godfrey-Faussett, Karimuribo, E. D.   +54 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Calcium/sodium exchange in purified secretory vesicles from bovine neurohypophyses [PDF]

, 1983
Purified secretory vesicles isolated from bovine neurohypophyses take up Na+ under the same circumstances where an efflux of Ca2+ takes place, suggesting a Na+/Ca2+ exchange. Potassium cannot substitute for Na+ in this process. Also, a Ca2+/Ca2+ exchange
Thorn, N. A., Saermark, T., Gratzl, Manfred   +2 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Dubuquoy, Catherine, C., Eléouët, Jean-François, Soulestin, Marion, Deville, Sébastien, Durand, Guillaume, Meyer, Gilles, G., Bernard, Julie, Bernadet, Philippe, Bernardet, Philippe, Petit-Camurdan, Agnès, Schwartz-Cornil, Isabelle, Riffault, Sabine, Dubosclard, Virginie, Eleouet, Jean Francois, J. F., Meyer, Gilles, Castagné, Nathalie, Deplanche, Martine, Bernex, Florence, Dubuquoy, Catherine   +18 more
core   +1 more source