Results 31 to 40 of about 2,139 (156)

Case Report: Infantile Bullous Pemphigoid: Triggering by COVID-19 Is Speculative

Frontiers in Medicine, 2021
Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ ...
Anna Rosińska-Więckowicz, Magdalena Jałowska, Monika Bowszyc-Dmochowska, Marian Dmochowski   +3 more
doaj   +1 more source

Serological Insights into Bullous Pemphigoid: Comparative Diagnostic Performance and Their Association with Clinical Severity

Clinical Dermatology Review
Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease caused by autoantibodies targeting BP180 and BP230. We evaluated the diagnostic performance of anti-BP180-NC16A and anti-BP230 enzyme-linked immunosorbent assay (ELISA ...
Mohan Shendre, Tejashwini B, Chanabasappa Mendagudli, Sushma HR, Mitaxari Hugar, Shivakumar Belur   +5 more
doaj   +1 more source

Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

Orphanet Journal of Rare Diseases, 2021
Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the
Christian Schwarm, Damian Gola, Maike M. Holtsche, Anabelle Dieterich, Anita Bhandari, Miriam Freitag, Peter Nürnberg, Mohammad Toliat, Wolfgang Lieb, Michael Wittig, André Franke, Margitta Worm, Michael Sticherling, Jan Ehrchen, Claudia Günther, Regine Gläser, Wiebke K. Peitsch, Miklós Sárdy, Rüdiger Eming, Michael Hertl, Sandrine Benoit, Matthias Goebeler, Claudia Pföhler, Manfred Kunz, Alexander Kreuter, Nina van Beek, Jeanette Erdmann, Hauke Busch, Detlef Zillikens, Christian D. Sadik, Misa Hirose, Inke R. König, Enno Schmidt, Saleh M. Ibrahim, German AIBD Study Group   +34 more
doaj   +1 more source

Paraneoplastic Pemphigus Presenting as Mild Cutaneous Features of Pemphigus Foliaceus and Lichenoid Stomatitis with Antidesmoglein 1 Antibodies

Dermatology Research and Practice, 2010
Herein, we report a case of paraneoplastic pemphigus with mild skin features of pemphigus foliaceus and lichenoid stomatitis associated with B-cell lymphoma. A 49-year-old man presented with scattered blisters and erosions on the trunk along with mucosal
Yayoi Niimi, Bungo Ohyama, Giovanni Di Zenzo, Valentina Calabresi, Takashi Hashimoto, Seiji Kawana   +5 more
doaj   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Structural basis of integrin α6β4 interaction with the bullous pemphigoid antigen BP230 in hemidesmosomes

, 2018
Mechanical stability of epithelia requires firm attachment of the cells to the basement membrane via complexes named hemidesmosomes. Disorders that target hemidesmosomal proteins cause severe skin blistering diseases. In type I hemidesmosomes, present in
Alonso-Garcia, de Pereda, Jose Maria, Garcia-Rubio, Ines, Kreft, Maaike, Manso, Jose Antonio, Gomez-Hernandez, Maria, Carabias Del Rey, Arturo, Sonnenberg, Arnoud   +7 more
core   +1 more source

Effect and length of doxycycline administration in elderly patients with bullous pemphigoid

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Bullous pemphigoid (BP) is the most common autoimmune blistering disease and primarily affects the elderly. Systemic corticosteroids and immunosuppressive drugs are the standard treatment, but side effects often restrict their use. Doxycycline has been proposed as an alternative, but there is limited long‐term, real‐world data on its
Alena Merkel‐Ropele, Wolfgang Salmhofer, Peter Wolf   +2 more
wiley   +1 more source

Emerging Roles of PSTPIP2 in Autoimmunity: From Mechanism to Therapeutic Implications

Immunology, EarlyView.
PSTPIP2 acts as a key brake on myeloid inflammation by suppressing IL‐1β‐driven signalling, macrophage dysregulation and inflammation‐associated bone remodelling. Its emerging roles in CRMO/CMO, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid support its potential as a biomarker and therapeutic target.
Erdong Zhang, Fengyu Liu, Yongle Wei, Guoqiang Li, Liujie Zheng, Lin Jin, Feng Luan, Yingze Zhang, Ling Wang, Zhiyong Hou   +9 more
wiley   +1 more source

A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid

Dermatopathology, 2021
Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP.
Iria Neri, Valeria Evangelista, Alba Guglielmo, Andrea Sechi, Annalucia Virdi   +4 more
doaj   +1 more source

Incidence of P200 pemphigoid: A nationwide study

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1675-1681, October 2026.
The anti‐LAMB4 cell‐based immunoassay is a new serological technique that is far superior to dermal immunoblotting for detecting autoantibodies directed against the P200 protein. This method allows a re‐evaluation of the incidence of P200 pemphigoid, which appears to be considerably more frequent than epidermolysis bullosa acquisita.
Fabienne Jouen, Marion Carrette, Marie‐Laure Golinski, Maud Maho‐Vaillant, Alexis Lefebvre, André Gillibert, Pascal Joly, Vivien Hébert   +7 more
wiley   +1 more source