Results 71 to 80 of about 44,634 (185)

Serping1 associated with α-synuclein increase in colonic smooth muscles of MPTP-induced Parkinson’s disease mice

Scientific Reports
Patients with Parkinson’s disease (PD) have gastrointestinal motility disorders, which are common non-motor symptoms. However, the reasons for these motility disorders remain unclear. Increased alpha-synuclein (α-syn) is considered an important factor in
Min Hyung Seo, Soo-Hwan Kim, Sujung Yeo
doaj   +1 more source

Reducing Brain Edema Using Berotralstat, an Inhibitor of Bradykinin, Repurposed as Treatment Adjunct in Glioblastoma

Neuroglia
Glioblastomas synthesize, bear receptors for, and respond to bradykinin, triggering migration and proliferation. Since centrifugal migration into uninvolved surrounding brain tissue occurs early in the course of glioblastoma, this attribute defeats local
Richard E. Kast
doaj   +1 more source

TRPV1 blockade restores the baroreflex control of renal sympathetic nerve activity in cisplatin‐induced renal injury in rats

Experimental Physiology, EarlyView.
Abstract Renal injury is associated with inflammatory responses within the kidney which could involve activation of transient receptor potential vanilloid 1 (TRPV1) channels. This study investigated whether TRPV1 channels modulate baroreflex regulation of renal sympathetic nerve activity (RSNA) in a rat model of cisplatin‐mediated renal injury.
Mohammed H. Abdulla, Ella Murphy, Lauren Mulcahy, Edward J. Johns   +3 more
wiley   +1 more source

Alu insertion/deletion of ACE gene polymorphism might not affect significantly the serum bradykinin level in hypertensive patients taking ACE inhibitors

Egyptian Journal of Medical Human Genetics, 2017
Background: Angiotensin I-converting enzyme (ACE) has two homologous catalytic domains, the N- and C-domains. Our previous study suggested that Alu insertion (I allele) in the intron 16 of ACE resulted in premature codon termination.
Widodo, Shila Wisnasari, Mohammad Saifur Rohman, Lowry Yunita, Mifetika Lukitasari, Maulidiyatun Nuril, Kholifah Holil, Dian Laila Purwaningroom   +7 more
doaj   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Angioedema: Classification, management and emerging therapies for the perioperative physician

Indian Journal of Anaesthesia, 2016
Angioedema is a rare condition which manifests as sudden localised, non-pitting swelling of certain body parts including skin and mucous membranes.
Lopa Misra, Narjeet Khurmi, Terrence L Trentman   +2 more
doaj   +1 more source

Interaction of the renin–angiotensin system, bradykinin and sympathetic nerves with cholinergic transmission in the rat isolated trachea [PDF]

, 1997
Maurice E. Fabiani, Diem Dinh, David Story   +2 more
openalex   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Local L‐NG‐monomethyl‐arginine attenuates the vasodilator action of bradykinin in the human forearm. [PDF]

, 1994
KP O'Kane, DJ Webb, JG Collier, PJ Vallance   +3 more
openalex   +1 more source

Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates

The Journal of Physiology, EarlyView.
Abstract figure legend Differences in cardiovascular function between appropriately grown (AG) and fetal growth restricted (FGR) infants after the cardiopulmonary transition at birth. AG infants typically exhibit an increase in left ventricular output (LVO) and stroke volume (SV) in the first few days after birth, along with a reduction in myocardial ...
Zahrah Azman, Arvind Sehgal, Suzanne L. Miller, Kristen J. Bubb, Graeme R. Polglase, Beth J. Allison   +5 more
wiley   +1 more source