Results 81 to 90 of about 1,270,647 (242)
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Bradykinin Receptor Modulation in Vein Grafts
Journal of Investigative Surgery, 1994 Following vein grafting, bradykinin B2 receptor-mediated responses in the vein graft are decreased and B1 receptor-mediated responses are increased. It is not known whether these changes in bradykinin receptor responses are due to nonspecific changes, local inflammation, or arterial hemodynamics.
M G, Davies, P O, Hagen
openaire +2 more sources
Papel do receptor ativado por proteinases-2 (par-2) no comportamento de coçar em camundongos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos no
Costa, Robson da
core
CD93—An emerging vascular target in cancer therapy
British Journal of Pharmacology, EarlyView.Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White +5 more
wiley +1 more source
Induction of bradykinin B1 receptor in rats
Folia Pharmacologica Japonica, 1997 We found the time-dependent induction of the systemic hypotensive response to des-Arg9-bradykinin and the contractile response of ileum of rats to des-Arg9-bradykinin. Both induced responses to des-Arg9-bradykinin were inhibited by treatment with a B1 receptor competitive antagonist, while the responses to bradykinin was constant throughout the ...
UENO, Akinori, OH-ISHI, Sachiko
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The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis
International Endodontic Journal, EarlyView.ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson +3 more
wiley +1 more source
Drugs and Drug CandidatesAngiotensin-converting enzyme (ACE) inhibitors (ACEis) are one of the most successful drug classes for the treatment of hypertension and the prevention of its cardiovascular complications.
François Marceau
doaj +1 more source
Frontiers in Aging Neuroscience, 2019 Functional magnetic resonance imaging (fMRI) techniques can be used to assess cerebrovascular dysfunction in Alzheimer’s disease, an important and early contributor to pathology. We hypothesized that bradykinin receptor inhibition alleviates the vascular
Ruiqing Ni +16 more
doaj +1 more source