Estudos farmacológicos e bioquímicos dos mecanismos envolvidos na regulação da expressão do receptor B1 para as cininas [PDF]
, 2001 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O presente estudo avaliou, através de técnicas moleculares e farmacológicas, o efeito dos glicocorticóides endógenos sobre
Cabrini, Daniela de Almeida
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Andrology, EarlyView.ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang +4 more
wiley +1 more source
The in vivo characterisation of a C-domain specific ACE inhibitor [PDF]
, 2013 Includes bibliographical references.The ACE protein is a zinc-dependent dipeptidyl carboxypeptidase comprised of two homologous domains termed the C- and N-domain.
Sharp, Sarah-Kate
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A Thorough Training in Modern Drug Design
CHIMIA, 2006 The laboratory class Modern Drug Design at the Department of Pharmacy of the University of Basel offers the students a thorough training in modern drug design. First, antagonists for the Bradykinin B2 receptor are designed using state-of-the-art
Angelo Vedani +3 more
doaj +1 more source
Effects of a novel bradykinin B1 receptor antagonist and angiotensin II receptor blockade on experimental myocardial infarction in rats. [PDF]
PLoS ONE, 2012 The aim of the present study was to evaluate the cardiovascular effects of the novel bradykinin B1 receptor antagonist BI-113823 following myocardial infarction (MI) and to determine whether B1 receptor blockade alters the cardiovascular effects of an ...
Dongmei Wu +4 more
doaj +1 more source
Genetic alterations in epilepsy: the cases of Unverricht- Lundborg disease, Fragile X and B1 null mutation [PDF]
, 2009 Genetic mechanisms are estimated to underlie about 40% of epilepsies and may present with different manifestations and syndromes. In this thesis, three different cases of genetic implications in epilepsy have been studied: Unverricht-Lundborg disease ...
Buzzi, Andrea
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Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Respiratory Research, 2010 Background Nicotine plays an important role in cigarette-smoke-associated airway disease. The present study was designed to examine if nicotine could induce airway hyperresponsiveness through kinin receptors, and if so, explore the underlying mechanisms ...
Cardell Lars-Olaf, Zhang Yaping, Xu Yuan
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The role of bradykinin in lung ischemia-reperfusion injury in a rat lung transplantation model [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE: To investigate the role of bradykinin in a rat lung transplantation (LTx) model and preliminarily discuss the relationship between bradykinin and CD26/DPP-4.
Zheng Tang +5 more
doaj +2 more sources
Caracterização do receptor e dos mecanismos relacionados a resposta inflamatoria induzida pela des-Arg9-bradicinina no modelo murino de pleurisia [PDF]
, 1998 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias BiologicasCaracterização do receptor B1, e dos mecanismos relacionados à resposta inflamatória induzida pela des-Arg9-bradicinina na cavidade pleural de camundongos.
Vianna, Rose Mari Jacobesen
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