Results 61 to 70 of about 1,270,647 (242)

Serping1 associated with α-synuclein increase in colonic smooth muscles of MPTP-induced Parkinson’s disease mice

Scientific Reports
Patients with Parkinson’s disease (PD) have gastrointestinal motility disorders, which are common non-motor symptoms. However, the reasons for these motility disorders remain unclear. Increased alpha-synuclein (α-syn) is considered an important factor in
Min Hyung Seo, Soo-Hwan Kim, Sujung Yeo
doaj   +1 more source

Where Eastern Medicine Meets Western Medicine: A World Review of the Management of Chronic Cough

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Purpose To summarize current Western and Eastern approaches to the evaluation and management of chronic cough, with particular emphasis on etiology‐directed therapy, cough hypersensitivity, behavioral interventions, neuromodulators, procedural treatments, and traditional remedies.
Thomas Zheng Jie Teng, Zhi Xuan Koh, Justin Yi Shen Lim, Kavimalar Ravi, Jin Wayne Kyler Ong, Christina Hui Lee Ng   +5 more
wiley   +1 more source

Bradykinin and adenosine receptors mediate desflurane induced postconditioning in human myocardium: role of reactive oxygen species

BMC Anesthesiology, 2010
Background Desflurane during early reperfusion has been shown to postcondition human myocardium, in vitro. We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in ...
Gérard Jean-Louis, Massetti Massimo, Babatasi Gérard, Ivascau Calin, Rouet René, Buléon Clément, Lemoine Sandrine, Hanouz Jean-Luc   +7 more
doaj   +1 more source

Intraprocedural Hemodynamics During Concomitant Rheocarna Therapy and Maintenance Hemodialysis: Effects of Dialyzer Membrane Type and Circuit Sequence. [PDF]

J Clin Apher
ABSTRACT Chronic limb‐threatening ischemia (CLTI), a severe manifestation of peripheral artery disease, is particularly prevalent among patients receiving maintenance hemodialysis (HD) and is associated with poor limb and survival outcomes. Low‐density lipoprotein (LDL) apheresis, including Rheocarna, is used as adjunctive therapy for refractory CLTI ...
Ishizuka Y, Sato G, Ishigaki S, Enoki R, Kajiwara K, Nakasato A, Kinomura S, Kin S, Noguchi Y, Yoshizawa D, Kikuchi K, Abe M, Kumagai K, Tanaka T, Okamoto K.   +14 more
europepmc   +2 more sources

Real‐World Safety and Effectiveness of Icatibant in Patients With Hereditary Angioedema (HAE): Post‐Marketing Surveillance in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare, autosomal dominant, life‐threatening disease characterized by recurrent attacks of swelling of the face, upper airway, gastrointestinal tract, limbs, and/or genitalia. Genetic mutations of the SERPING1 gene encoding the C1‐inhibitor (C1‐INH) plasma protein are associated with HAE‐C1INH.
Kumiko Hosono, Miyako Hoshino
wiley   +1 more source

Neuroprotection of bradykinin/bradykinin B2 receptor system in cerebral ischemia

Biomedicine & Pharmacotherapy, 2017
Bradykinin B2 receptor (B2R) activated by its endogenous ligand bradykinin participates in various physiological processes including neurogenesis, neuronal differentiation, and control of inflammation and blood pressure. Besides these effects, B2R has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury.
Bingyuan, Ji, Baohua, Cheng, Yanyou, Pan, Chunmei, Wang, Jing, Chen, Bo, Bai   +5 more
openaire   +2 more sources

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Thromboxane A2 mediates cation-induced airway hyperresponsiveness through the bradykinin B2 receptor in guinea pigs

Allergology International, 1999
To elucidate the mechanisms of cationic protein-induced airway hyperresponsiveness (AHR), the airway response to methacholine, and the concentrations of thromboxane B2 (TXB2) and 6-keto-PGF1α in the bronchoalveolar lavage fluid (BALF) of guinea-pigs were
Tomohiko Shirotani, Hitoshi Maeda, Yoshihiro Nishimura, Mitsuhiro Yokoyama   +3 more
doaj   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Tatulian, L, Hughes, S, Brown, DA, Marsh, SJ, Winks, JS, Filippov, AK   +6 more
core  

Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations

Allergy, EarlyView.
ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow   +14 more
wiley   +1 more source