Results 151 to 160 of about 567,455 (203)

New selective bradykinin receptor antagonists and bradykinin B2 receptor characterization

Trends in Pharmacological Sciences, 1990
Substantial progress has been made recently in the field of kinin pharmacology with the identification of sensitive bioassay organs and the discovery of bradykinin B2 receptor antagonists. Data obtained with such compounds in various laboratories support the hypothesis that kinins act on multiple (at least two) receptor types.
D, Regoli, N E, Rhaleb, S, Dion, G, Drapeau   +3 more
openaire   +2 more sources

Bradykinin Receptors in Ischemic Injury

Current Neurovascular Research, 2019
Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation,
Min, Tang, Fangping, He, Li, Ma, Ping, Liu, Jianwen, Wang, Xiongchao, Zhu   +5 more
openaire   +2 more sources

Receptors for bradykinin in rabbit aortae

Canadian Journal of Physiology and Pharmacology, 1977
Rabbit aorta strips respond to bradykinin (BK) and to the C-terminal fragment of BK, the octapeptide 1-8 BK (Octa) with sustained contractions which are presumably due to the stimulation of specific receptors, because they remain unchanged in presence of phentolamine, methysergide, mepyramine, 8-Leu-ATII, and indomethacin.
D, Regoli, J, Barabé, W K, Park
openaire   +2 more sources

Theoretical Study of the Human Bradykinin–Bradykinin B2 Receptor Complex

ChemBioChem, 2008
AbstractThe interaction of bradykinin (BK) with the bradykinin B2 receptor (B2R) was analyzed by using molecular modeling (MM) and molecular dynamics (MD) simulations. A homology model for B2R has been generated and the recently determined receptor‐bound solid‐state NMR spectroscopic structure of BK (Lopez et al., Angew. Chem.
Artur Giełdoń, Jakob J. Lopez, Clemens Glaubitz, Harald Schwalbe   +3 more
openaire   +2 more sources

The Bradykinin B2-Receptor in Human Decidua

Seminars in Thrombosis and Hemostasis, 1999
Bacterial infection of the amniotic cavity is one of the most frequent causes of preterm delivery. Bacterial products activate a network of autocrine and paracrine mediators in fetal membranes and decidua, with prostaglandins finally inducing contractions of the myometrium. Bradykinin and its B2-receptor (B2R) seem to be part of this network.
P, Buchinger, J, Rehbock
openaire   +2 more sources

Regulation of Bradykinin Action at the Receptor Level

Journal of Cardiovascular Pharmacology, 1990
Intact cultured human foreskin fibroblasts can be used as an in vitro system to study the regulatory events related to kinin receptor function. Specific bradykinin (BK) receptor sites (B2 subtype) were measured by direct binding study and correlated with BK-induced biological effects such as the release of inositol phosphates, formation of prostacyclin
A A, Roscher, C, Klier, R, Dengler, A, Faussner, W, Müller-Esterl   +4 more
openaire   +2 more sources

Differential Contribution of Bradykinin Receptors in Angiogenesis

2000
Bradykinin (BK) contributes to the inflammatory response inducing vasodilation of postcapillary venules and has been demonstrated to induce neovascular growth in subcutaneous rat sponges. In this study the ability of BK to stimulate cell growth and migration in cultured endothelium from coronary postcapillary venules (CVEC) has been investigated.
Morbidelli, Lucia, Parenti, A., Donnini, Sandra, Granger, H. J., Ledda, F., Ziche, Marina   +5 more
openaire   +4 more sources

Advances in the Development of Bradykinin Receptor Ligands

Current Topics in Medicinal Chemistry, 2006
Kinins are blood-derived local-acting peptides that elicit specific cellular effects via the stimulation of two related G protein coupled receptors. While the B(2)receptor subtype, constitutively expressed in various tissues, is believed to mediate most of the physiological actions of kinins in healthy conditions, the B(1) receptor, highly regulated ...
Jean-Philippe, Fortin, François, Marceau   +1 more
openaire   +2 more sources

Bradykinin receptor types and B2 subtypes

Life Sciences, 1994
Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig ileum, two widely used B2 preparations which have shown marked differences in their ...
D, Regoli, F, Gobeil, Q T, Nguyen, D, Jukic, P R, Seoane, J M, Salvino, D G, Sawutz   +6 more
openaire   +2 more sources

Expression and function of bradykinin receptors in microglia

Life Sciences, 2003
Expression of bradykinin (BK) receptors and their cellular function were investigated in microglia. Microglial cells were isolated from mixed cultures of cerebrocortical cells from postnatal day 3 Wistar rats. Reverse transcription-PCR (RT-PCR) showed that rat primary microglia express mRNAs for the type 2 bradykinin (B(2)) receptor subtype but not the
Mami, Noda, Yukihiro, Kariura, Taiju, Amano, Yoshimasa, Manago, Kaori, Nishikawa, Shunsuke, Aoki, Keiji, Wada   +6 more
openaire   +2 more sources