Results 161 to 170 of about 567,455 (203)

Recent developments in the understanding of bradykinin receptors

Life Sciences, 1992
The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growth, and leukocyte activation have ...
R M, Burch, D J, Kyle
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Characterization of bradykinin receptors in peripheral organs

Canadian Journal of Physiology and Pharmacology, 1991
Bradykinin (BK) and related kinins are potent stimulants of the rabbit jugular vein, the hamster urinary bladder, and the guinea pig trachea. The characterization of kinin receptors in these tissues was made with agonists and antagonists. Results obtained with agonists indicate that bradykinin and kallidin are much more active than des-Arg9-BK and ...
N E, Rhaleb, N, Rouissi, G, Drapeau, D, Jukic, D, Regoli   +4 more
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Bradykinin receptor ligands: therapeutic perspectives

Nature Reviews Drug Discovery, 2004
Kinins, which are produced by the action of kallikrein enzymes, are blood-derived local-acting peptides that have broad effects mediated by two related G-protein-coupled receptors termed the bradykinin receptors. The endogenous kallikrein-kinin system controls blood circulation and kidney function, and promotes inflammation and pain in pathological ...
François, Marceau, Domenico, Regoli
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Therapeutic prospects of bradykinin receptor antagonists

General Pharmacology: The Vascular System, 1993
1. Bradykinin and related kinins may act on four types of receptors designated as B1, B2, B3 and B4. It seems that the B2 receptors are most commonly found in various vascular and non-vascular smooth muscles, whereas B1 receptors are formed in vitro during trauma, and injury, and are found in bone tissues. 2.
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Intracellular and nuclear bradykinin B2 receptors

European Journal of Pharmacology, 2014
Bradykinin is a vasoactive peptide that participates in numerous inflammatory processes, vasodilation, and cell growth/survival; it mainly acts through two receptor subtypes, bradykinin B1 and bradykinin B2 receptors, which are G protein-coupled receptor (GPCR) family members.
Masaoki Takano, Shogo Matsuyama
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From Bradykinin B2 Receptor Antagonists to Orally Active and Selective Bradykinin B1 Receptor Antagonists

Journal of Medicinal Chemistry, 2012
The bradykinin (BK) B1 receptor is an attractive target for the treatment of chronic pain and inflammation. Starting from a dual B1 and B2 antagonist, novel antagonists were designed that display low-nanomolar affinity for human B1 receptor and selectivity over B2.
Martine, Barth, Michel, Bondoux, Jean-Michel, Luccarini, Vincent, Peyrou, Pierre, Dodey, Didier, Pruneau, Christine, Massardier, Jean-Luc, Paquet   +7 more
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Airway Bradykinin Receptors

Annals of the New York Academy of Sciences, 1991
S G, Farmer, R M, Burch
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Bradykinin receptor antagonists.

IDrugs : the investigational drugs journal, 2005
A review of the recent patent literature for bradykinin B2 receptor antagonists is presented for the period of 1994 to 1998. Although several very potent and selective peptide antagonists of bradykinin receptors are already known, the increasing number of recently disclosed patent applications claiming non-peptide B2 antagonists represents substantial ...
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Differentiation of Bradykinin Receptors and of Kininases with Conformational Analogues of Bradykinin

Molecular Pharmacology, 1978
L E, LeDuc, G R, Marshall, P, Needleman
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Bradykinin Receptors

2007
Domenico Regoli, Francois Marceau
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