Results 231 to 240 of about 198,722 (342)

Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer-a systematic review and meta-analysis. [PDF]

JNCI Cancer Spectr
Saqi IK, Nielsen AT, Madsen MT, Gögenur I, Orhan A, Justesen TF.   +5 more
europepmc   +1 more source

Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma

Nature Medicine, 2019
A. Ribas, D. Lawrence, V. Atkinson, S. Agarwal, Wilson H. Miller, Wilson H. Miller, M. Carlino, R. Fisher, G. Long, F. Hodi, J. Tsoi, C. Grasso, B. Mookerjee, Qing Zhao, R. Ghori, B. H. Moreno, N. Ibrahim, O. Hamid   +17 more
semanticscholar   +1 more source

Clinical Outcomes of Dacarbazine After Failure of Immune Checkpoint Inhibitors: A Case Study of 15 Japanese Patients With Malignant Melanoma

The Journal of Dermatology, EarlyView.
Ken Horisaki, Shusuke Yoshikawa, Wataru Omata, Arata Tsutsumida, Yoshio Kiyohara   +4 more
wiley   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers. [PDF]

MedComm (2020)
Yang K, Fu S, Liang J, Ding L, You J, Li F, Yuan Y, Bian XW.   +7 more
europepmc   +1 more source

Clinical and Genetic Landscape of Glioblastoma, IDH‐Wildtype With FGFR Gene Family Alterations

Cancer Science, EarlyView.
We analyzed 1076 cases of glioblastoma, IDH‐wildtype (GBM, IDH‐wt) using the C‐CAT genomic database to clarify the clinical and genetic features of FGFR alterations. FGFR::TACC fusions and FGFR1 mutations were identified in distinct subsets and were associated with unique co‐mutation patterns.
Yasuhito Kegoya, Yoshihiro Otani, Ryo Mizuta, Ryosuke Ikemachi, Mako Kamiura, Joji Ishida, Shinichi Toyooka, Daisuke Ennishi, Shuta Tomida, Shota Tanaka   +9 more
wiley   +1 more source

Phosphorylations of serines 21/9 in glycogen synthase kinase 3α/β are dispensable for V600EBRAF-driven premalignant tumour development in the mouse intestine. [PDF]

PLoS One
Farahmand P, Rzasa P, Green C, Hey F, Giblett S, Jin H, West K, Sylvius NB, Pritchard CA, Rufini A.   +9 more
europepmc   +1 more source

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer [PDF]

, 2019
Baranski, Thomas, DeWees, Todd, Grigsby, Perry, Henke, Lauren, Lin, Alexander J, Markovina, Stephanie, Pfeifer, John, Samson, Pamela, Schwarz, Julie   +8 more
core   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, EarlyView.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

Case Report: Molecular diagnostics and clinical courses of two adult spinal pilocytic astrocytoma long-term survivors with GTF2I::BRAF fusion. [PDF]

Front Oncol
Argao L, Zerk PE, Lu HC, Abdullaev Z, Quezado M, Cassidy ML, Mclver B, Choi A, Panzer M, Tweneboah-Koduah R, Polskin L, Penas-Prado M, Park P, Clarke N, Aldape K, Mandel J, Ozer BH.   +16 more
europepmc   +1 more source