Results 41 to 50 of about 198,722 (342)

Indirect treatment comparison of dabrafenib plus trametinib versus vemurafenib plus cobimetinib in previously untreated metastatic melanoma patients. [PDF]

, 2017
BackgroundMetastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies.
Ahuja, Amit, Chen, Lei, Daud, Adil, Gill, Japinder, Kamra, Sheily   +4 more
core   +2 more sources

BRAF-Mutated Non-Small Cell Lung Cancer: Current Treatment Status and Future Perspective

Frontiers in Oncology, 2022
V-Raf murine sarcoma viral oncogene homolog B (BRAF) kinase, which was encoded by BRAF gene, plays critical roles in cell signaling, growth, and survival. Mutations in BRAF gene will lead to cancer development and progression.
N. Yan, Sanxing Guo, Huixian Zhang, Ziheng Zhang, S. Shen, Xingya Li   +5 more
semanticscholar   +1 more source

The development of potential targets in the treatment of non-small cell lung cancer

Open Life Sciences, 2016
The oncogenic driver mutations have been found that not only have potential sensitivity to epidermal growth factor receptor but also can inhibit anaplastic lymphoma kinase tyrosine kinase; more and more interest has been evoked in discovering additional ...
Zhang Jimin, Lin Zhihui
doaj   +1 more source

Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406).

Journal of Clinical Oncology, 2020
PURPOSE BRAFV600E mutations are rarely associated with objective responses to the BRAF inhibitor vemurafenib in patients with metastatic colorectal cancer (CRC).
S. Kopetz, K. Guthrie, V. Morris, H. Lenz, Anthony M. Magliocco, D. Maru, Yibing Yan, R. Lanman, G. Manyam, David S Hong, Alexey Sorokin, C. Atreya, Luis A. Diaz, C. Allegra, K. Raghav, Stephen E. Wang, Christopher H Lieu, Shannon L. McDonough, P. Philip, H. Hochster   +19 more
semanticscholar   +1 more source

KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer – practical implications for the clinician

Radiology and Oncology, 2019
Colorectal cancer is a successful model of genetic biomarker development in oncology. Currently, several predictive or prognostic genetic alterations have been identified and are used in clinical practice.
Afrăsânie Vlad-Adrian, Marinca Mihai Vasile, Alexa-Stratulat Teodora, Gafton Bogdan, Păduraru Marius, Adavidoaiei Anca Maria, Miron Lucian, Rusu Cristina   +7 more
doaj   +1 more source

The cost-effectiveness of nivolumab monotherapy for the treatment of advanced melanoma patients in England [PDF]

, 2018
Background: Nivolumab was the first programmed death receptor 1 (PD-1) immune checkpoint inhibitor to demonstrate long-term survival benefit in a clinical trial setting for advanced melanoma patients.
Ellis, John, Hertel, Nadine, Johnson, Helen, Lee, Dawn, Meng, Yang, Morais, Edith, Philips, Zoe, Roskell, Neil, Walker, Andrew   +8 more
core   +1 more source

Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2017
An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Han, Qinghong, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miyake, Kentaro, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Tan, Yuying, Unno, Michiaki   +15 more
core   +2 more sources

Melanoma BRAF Fusions—Letter [PDF]

Clinical Cancer Research, 2014
We read with interest the article by Hutchinson and colleagues ([1][1]) describing melanomas harboring BRAF fusions and their sensitivity to MEK inhibition. We also have reported recurrent BRAF fusions in melanocytic neoplasms, including melanomas, and would like to comment on some of ...
Thomas, Botton, Iwei, Yeh, Boris C, Bastian   +2 more
openaire   +2 more sources

Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways

Open Medicine, 2020
In 2010, serrated polyps (SP) of the colon have been included in the WHO classification of digestive tumors. Since then a large corpus of evidence focusing on these lesions are available in the literature.
Sacco Michele, De Palma Fatima Domenica Elisa, Guadagno Elia, Giglio Mariano Cesare, Peltrini Roberto, Marra Ester, Manfreda Andrea, Amendola Alfonso, Cassese Gianluca, Dinuzzi Vincenza Paola, Pegoraro Francesca, Tropeano Francesca Paola, Luglio Gaetano, De Palma Giovanni Domenico   +13 more
doaj   +1 more source

Targeted Therapy in the Management of Modern Craniopharyngiomas

Frontiers in Bioscience-Landmark, 2022
Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures can lead to a host of neurologic and endocrine complications that lead to difficulty with surgical management. In this review, we examine the molecular and genetic
Maikerly Reyes, Mohammad Taghvaei, Siyuan Yu, Anish Sathe, Sarah Collopy, Giyarpuram N. Prashant, James J. Evans, Michael Karsy   +7 more
doaj   +1 more source