Results 11 to 20 of about 244,575 (365)

Brain-derived Neurotrophic Factor in Megakaryocytes [PDF]

open access: yesJournal of Biological Chemistry, 2016
The biosynthesis of endogenous brain-derived neurotrophic factor (BDNF) has thus far been examined in neurons where it is expressed at very low levels, in an activity-dependent fashion. In humans, BDNF has long been known to accumulate in circulating platelets, at levels far higher than in the brain.
Pedro Chacón-Fernández   +5 more
openaire   +5 more sources

Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor regulate the interaction between astrocytes and Schwann cells at the trigeminal root entry zone

open access: yesNeural Regeneration Research, 2023
The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central oligodendrocytes. Its special anatomical and physiological structure renders it susceptible to nerve injury.
Madeha Ishag Adam   +8 more
doaj   +1 more source

Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

open access: yesTranslational Neurodegeneration, 2022
Synaptic abnormalities are a cardinal feature of Alzheimer’s disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic ...
Li Gao   +3 more
semanticscholar   +1 more source

Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases

open access: yesInternational Journal of Molecular Sciences, 2022
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in ...
Khairunnuur Fairuz Azman, R. Zakaria
semanticscholar   +1 more source

Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

open access: yesWorld Journal of Psychiatry, 2022
Major depressive disorder is a debilitating disorder affecting millions of people each year. Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received ...
Grace A. Porter, J. O'Connor
semanticscholar   +1 more source

Acute effects of two different work-to-rest ratio of high-intensity interval training on brain-derived neurotrophic factor in untrained young men

open access: yesFrontiers in Physiology, 2022
Background: Aerobic exercise could produce a positive effect on the brain by releasing brain-derived neurotrophic factor (BDNF). In untrained healthy humans there seems to be a linear correlation between exercise duration and the positive effect of acute
Kegang Zhao   +7 more
doaj   +1 more source

The role of brain derived neurotrophic factor in central nervous system

open access: yesFrontiers in Aging Neuroscience, 2022
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological
Yiyi Li   +11 more
semanticscholar   +1 more source

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