Results 101 to 110 of about 2,666,950 (303)

New technologies to investigate the brain-gut axis

World Journal of Gastroenterology, 2009
Functional gastrointestinal disorders are commonly encountered in clinical practice, and pain is their commonest presenting symptom. In addition, patients with these disorders often demonstrate a heightened sensitivity to experimental visceral stimulation, termed visceral pain hypersensitivity that is likely to be important in their pathophysiology ...
Sharma, Abhishek, Lelic, Dina, Brock, Christina, Paine, Peter, Aziz, Qasim   +4 more
openaire   +3 more sources

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Importance of good hosting: reviewing the bi-directionality of the microbiome-gut-brain-axis

Frontiers in Neuroscience
Gut microorganisms have been shown to significantly impact on central function and studies that have associated brain disorders with specific bacterial genera have advocated an anomalous gut microbiome as the pathophysiological basis of several ...
Carolina F. F. A. Costa, Carolina F. F. A. Costa, Joana Ferreira-Gomes, Joana Ferreira-Gomes, Fernando Barbosa, Benedita Sampaio-Maia, Benedita Sampaio-Maia, Philip W. J. Burnet   +7 more
doaj   +1 more source

Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]

, 2018
It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Dinan, Timothy G., Kennedy, Paul J., Clarke, Gerard, Cryan, John F.   +3 more
core   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

From Flow to Function: Using Different Static Mixers to Fabricate Microarchitected Materials Via Chaotic Printing

Advanced Science, EarlyView.
Complex microarchitectures emerge from simple flow‐driven transformations as static mixers iteratively reorient and split material domains. Coupled with diverse deposition strategies, chaotic printing provides an accessible platform for fabricating architected materials that support biologically and chemically relevant processes. ABSTRACT Nature builds
Edna Johana Bolívar‐Monsalve, Carlos Fernando Ceballos‐González, Diego Alonso Quevedo‐Moreno, Irving Isaí Rendón‐Moreno, Ariel Cantoral‐Sánchez, Héctor Ambriz‐González, Mario Moisés Alvarez, Grissel Trujillo‐de Santiago   +7 more
wiley   +1 more source

Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula

Nature Communications
Brain regions that integrate multiple types of information (“convergence zones”) are crucial for the brain to generate coherent experiences and behaviors. The insula, known for its functional diversity, has been hypothesized as a key convergence hub, yet
Mijin Kwon, Ke Bo, Rotem Botvinik-Nezer, Philip A. Kragel, Lukas Van Oudenhove, Tor D. Wager, The Affective Neuroimaging Consortium   +6 more
doaj   +1 more source

Therapeutic role of gut microbiota in lung injury-related cognitive impairment

Frontiers in Nutrition
Lung injury can lead to specific neurocognitive dysfunction, and the “triple-hit” phenomenon may be the key theoretical mechanism for the progressive impairment of lung injury-related cognitive impairment.
Yanxia Cheng, Guangtao Hu, Lin Deng, Yalan Zan, Xia Chen   +4 more
doaj   +1 more source

The Gut–Brain–Muscle Axis: Microbial Regulation of Neuromuscular Aging and Cognitive Frailty

Cognitive frailty, characterized by the coexistence of physical frailty and cognitive impairment, has emerged as a major challenge in aging populations and is closely linked to sarcopenia, neurodegeneration, and chronic inflammation.
Nurpudji Astuti Taslim, Jeremy Nicolas Sibarani, Happy Kurnia Permatasari, Ricky Indra Alfaray, Nelly Mayulu, Dian Aruni Kumalawati, Fahrul Nurkolis, Raymond Rubianto Tjandrawinata, Arifa Mustika   +8 more
core   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source