Results 251 to 260 of about 166,999 (286)

Brain cholesterol homeostasis and its association with neurodegenerative diseases

Neurochemistry International, 2023
The brain is the most cholesterol-rich organ in mammals. However, cholesterol metabolism in the brain is completely independent of other tissues due to the presence of the blood-brain barrier (BBB). Neurons, astrocytes and oligodendrocytes are the main cells responsible for cholesterol synthesis in the brain.
Yi Gao, Shiying Ye, Yuehong Tang, Wenjuan Tong, Shaowei Sun   +4 more
openaire   +4 more sources

TMET-05. LIPOPHAGY CONTROLS CHOLESTEROL HOMEOSTASIS AND BRAIN TUMOR GROWTH

Neuro-Oncology, 2023
Abstract Cholesterol is an essential structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels of membrane cholesterol, but with an abundant presence of cholesteryl ...
Feng Geng, Yaogang Zhong, Huali Su, Etienne Lefai, William Yong, Arnab Chakravarti, Deliang Guo   +6 more
openaire   +1 more source

Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis

European Journal of Neuroscience, 2020
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Aβ plaques and tauopathy are two major concerns associated with AD. Moreover, excessive Aβ accumulation can lead to other nonspecific metabolic brain abnormalities.
Nikita Patil Samant, Girdhari Lal Gupta
openaire   +2 more sources

Brain cholesterol homeostasis in Wilson disease

Medical Hypotheses, 2013
Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism, resulting in pathological accumulation of Cu in many organs and tissues, predominantly in the liver and brain. There clearly is a close and complex relationship between Cu and the cholesterol's metabolic pathway; therefore any theory about the cholesterol ...
CACCIATORE, STEFANO, TENORI, LEONARDO
openaire   +3 more sources

Hypoxia-Ischemia Brain Damage Disrupts Brain Cholesterol Homeostasis in Neonatal Rats

Neuropediatrics, 2009
The first 3 weeks of life is the peak time of oligodendrocytes development and also the critical period of cholesterol increasing dramatically in central nervous system in rats. Neonatal hypoxia-ischemia (HI) brain damage happening in this period may disturb the brain cholesterol balance as well as white matter development.To test this hypothesis ...
Z, Yu, S, Li, S H, Lv, H, Piao, Y H, Zhang, Y M, Zhang, H, Ma, J, Zhang, C K, Sun, A P, Li   +9 more
openaire   +2 more sources

Cholesterol homeostasis in the developing brain: a possible new target for ethanol

Human & Experimental Toxicology, 2007
Cholesterol is an essential component of cell membranes and plays an important role in signal transduction. This brief overview presents evidence from the literature that ethanol may affect cholesterol homeostasis and that, in the developing brain, this may be involved in its developmental neurotoxicity.
GUIZZETTI M, COSTA, Lucio Guido
openaire   +3 more sources

Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline

Current Medicinal Chemistry, 2014
Cholesterol is one of the most important molecules in cell physiology because of its involvement in several biological processes: for instance, it determines both physical and biochemical properties of cell membranes and proteins. Disruption to cholesterol homeostasis leads to coronary heart disease, atherosclerosis and metabolic syndrome.
SEGATTO, MARCO, Leboffe, Loris, Trapani, Laura, Pallottini, Valentina   +3 more
openaire   +4 more sources

Glutamate affects cholesterol homeostasis within the brain via the up-regulation of CYP46A1 and ApoE

Toxicology, 2020
Chronic glutamate excitotoxicity has been thought to be involved in numerous neurodegenerative disorders. A small but significant loss of membrane cholesterol has been reported following a short stimulation of ionotropic glutamate receptors (iGluRs). We investigated the alteration of brain cholesterol following chronic glutamate treatment.
Junjie, Zhang, Furong, Zhang, Juan, Wu, Jie, Li, Zheqiong, Yang, Jiang, Yue   +5 more
openaire   +2 more sources

Roles of glia cells in cholesterol homeostasis in the brain

2003
Publisher Summary This chapter discusses that the brain is a cholesterol-rich organ, and increasing evidence suggests that cholesterol plays a number of key roles in the central nervous system (CNS) through regulation of membrane functions and by other mechanisms.
Jin-ichi Ito, Shinji Yokoyama
openaire   +1 more source