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Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis
European Journal of Neuroscience, 2020Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Aβ plaques and tauopathy are two major concerns associated with AD. Moreover, excessive Aβ accumulation can lead to other nonspecific metabolic brain abnormalities.
Nikita Patil Samant, Girdhari Lal Gupta
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Glutamate affects cholesterol homeostasis within the brain via the up-regulation of CYP46A1 and ApoE
Toxicology, 2020Chronic glutamate excitotoxicity has been thought to be involved in numerous neurodegenerative disorders. A small but significant loss of membrane cholesterol has been reported following a short stimulation of ionotropic glutamate receptors (iGluRs). We investigated the alteration of brain cholesterol following chronic glutamate treatment.
Junjie, Zhang +5 more
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Biogerontology, 2009
Expression profiles of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), apolipoprotein E (ApoE) and cholesterol 24S-hydroxylase (CYP46), proteins involved in cholesterol biosynthesis, transport and excretion from the CNS, were analyzed in the rat cortex, hippocampus and cerebellum as a function of aging (6–24 months) and in response to long-term
Perović, Milka +6 more
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Expression profiles of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), apolipoprotein E (ApoE) and cholesterol 24S-hydroxylase (CYP46), proteins involved in cholesterol biosynthesis, transport and excretion from the CNS, were analyzed in the rat cortex, hippocampus and cerebellum as a function of aging (6–24 months) and in response to long-term
Perović, Milka +6 more
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Journal of Cellular Physiology, 2013
AbstractAlthough a great knowledge about the patho‐physiological roles of cholesterol metabolism perturbation in several organs has been reached, scarce information is available on the regulation of cholesterol homeostasis in the brain where this lipid is involved in the maintenance of several of neuronal processes.
SEGATTO, MARCO +3 more
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AbstractAlthough a great knowledge about the patho‐physiological roles of cholesterol metabolism perturbation in several organs has been reached, scarce information is available on the regulation of cholesterol homeostasis in the brain where this lipid is involved in the maintenance of several of neuronal processes.
SEGATTO, MARCO +3 more
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Medical Hypotheses, 2005
While excess cholesterol may have deleterious consequences, as in the case of atherosclerosis, too little cholesterol may endanger the development of the brain. Different degrees of mental retardation are often observed in inborn errors of cholesterol synthesis, such as the Smith-Lemli-Opitz syndrome or in maternal phenylketonuria, where the metabolite
GUIZZETTI M., COSTA, Lucio Guido
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While excess cholesterol may have deleterious consequences, as in the case of atherosclerosis, too little cholesterol may endanger the development of the brain. Different degrees of mental retardation are often observed in inborn errors of cholesterol synthesis, such as the Smith-Lemli-Opitz syndrome or in maternal phenylketonuria, where the metabolite
GUIZZETTI M., COSTA, Lucio Guido
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Quantifying brain cholesterol homeostasis
Nature Reviews Drug Discovery, 2022openaire +2 more sources
Alterations of Brain Cholesterol Homeostasis in the Tg2576 Mouse Model of Alzheimer's Disease
2018Background: It is now well established that perturbations in cholesterol levels are crucial in the onset and development of Alzheimer’s disease (AD). Despite this evidence, scarce information is available about prospective alterations of proteins controlling brain cholesterol homeostasis in Alzheimer’s disease. Thus, the aim of this work was to analyze
Pallottini, Valentina, Segatto, Marco
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Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis
European Journal of Neuroscience, 2021Nikita Patil Samant, Girdhari Lal Gupta
exaly
2016
Cholesterol is an essential molecule in central nervous system physiology and cell signalling, with a wide range of roles, such as being an essential component of cell membranes, lipid rafts and myelin sheets, or serving as a precursor for neurosteroids.
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Cholesterol is an essential molecule in central nervous system physiology and cell signalling, with a wide range of roles, such as being an essential component of cell membranes, lipid rafts and myelin sheets, or serving as a precursor for neurosteroids.
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Amyloid beta accumulation in HIV-1 infected brain: the role of altered cholesterol homeostasis.
Clinical research in HIV/AIDSThe long-term survival of HIV-1 infected individuals credited to the availability and use of effective antiretroviral therapy (ART) is unfortunately now accompanied by an almost 50% prevalence of HIV-1 associated neurocognitive disorder (HAND).
Xuesong, Chen +2 more
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