Soybean‐derived exosome‐like nanovesicles suppress lipid accumulation of adipocytes via UCP1/PGC‐1α mediated thermogenesis pathway and boosting mitochondrial function. ABSTRACT Obesity has become an important public health concern in modern society. Plant‐derived exosome‐like nanovesicles are emerging as candidates for obesity intervention.
Zhenzhu Zhu +5 more
wiley +1 more source
Altered brain vascularization and transcriptional changes in embryos lacking ABCA1 support a role of cholesterol in brain angiogenesis. [PDF]
Becerra B +12 more
europepmc +1 more source
Abstract BACKGROUND Obesity and its metabolic complications, such as insulin resistance and cognitive decline, remain a global health challenge. Green tea (Camelia sinensis) and ω‐3 polyunsaturated fatty acids (PUFAs) are recognized for their antioxidant, anti‐inflammatory, and neuroprotective properties.
Paola Finetti‐Casanova +5 more
wiley +1 more source
Sex- and age-dependent mitochondrial dysfunction and cognitive impairment in a mouse model of familial hypercholesterolemia. [PDF]
Prado-Lopes N +11 more
europepmc +1 more source
Cyclodextrin-Based Strategies for Brain Drug Delivery: Mechanistic Insights into Blood-Brain Barrier Transport and Therapeutic Applications. [PDF]
Vasilica PDF +9 more
europepmc +1 more source
Beyond ATP: Lipid-Driven Plasticity and the Immunometabolism of ILC2s. [PDF]
Pesold VV +3 more
europepmc +1 more source
Lipid dysregulation as a convergent pathway linking environmental exposures to stroke. [PDF]
Santerre M, Shcherbik N, Sawaya BE.
europepmc +1 more source
Inherent Lipid Composition Abnormalities in Astrocytes Associated with Late-Onset Alzheimer's Disease (LOAD). [PDF]
Cohen BM +4 more
europepmc +1 more source
Biological relationship between Parkinson's disease and gallstone disease. [PDF]
Jiang C +7 more
europepmc +1 more source
Assessment of cholesterol homeostasis in the living human brain [PDF]
Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via cytochrome P450 46A1 (CYP46A1).
Ahmed Haider, Chunyu Zhao, Lu Wang
exaly +8 more sources

