Results 221 to 230 of about 105,966 (270)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Bioactive-Supplemented Infant Formulas and Early Gut-Immune-Endocrine Development: A Narrative Review. [PDF]

Int J Mol Sci
Scirè Calabrisotto S, Leonardi R, Guercio M, Barbato M, Carpinato C, Mattia C, Decembrino N, Palano GM, Ruggieri M, Betta P.   +9 more
europepmc   +1 more source

Cordyceps militaris Ethanol Extract Alleviates Hyperglycemia in Type 2 Diabetic Mice in Association With Gut Microbiota Modification

eFood, Volume 7, Issue 4, August 2026.
Cordyceps militaris ethanol extract (CME) shows potential for ameliorating glucose and lipid metabolism in T2DM mice. The improvements are correlated with the regulation of gut microbiota and increased short‐chain fatty acid levels, offering a novel perspective for future diabetes interventions.
Huanhuan Wen, Wenke Hu, Xinru Xu, Na Wu, Huangcong Ding, Haonan Wang, Xiaoyu Gao, Ligen Chen, Chao Zhao, Rong Shao, Wei Xu   +10 more
wiley   +1 more source

Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes

Glia, Volume 74, Issue 8, August 2026.
Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi, Katarzyna M. Tyc, Lauren Dain, Maryam Ashrafi Kheirabadi, Jennifer Hanco, Karli Mockenhaupt, Soha Munir, Adam McQuiston, Sandeep K. Singh, Tomasz Kordula   +9 more
wiley   +1 more source

Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1. [PDF]

Expert Rev Clin Pharmacol
Maiese K.
europepmc   +1 more source

Exercise‐Induced Extracellular Vesicles as Mediators of Mitochondrial Biogenesis and Insulin Sensitivity in Metabolic Adaptation

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Exercise stimulates the release of extracellular vesicles from metabolically active tissues. These vesicles transport regulatory cargos, including microRNAs, proteins, lipids, and metabolites, to target organs such as skeletal muscle, adipose tissue, liver, and vascular tissues.
Jian Wang, Lei Wu
wiley   +1 more source

Multi-Target-Directed Ligands (MTDLs) as Potential Therapeutic Candidates Targeting Multiple Pathogenic Factor of Alzheimer's Disease. [PDF]

CNS Neurosci Ther
Jung J, Kim Y, Cirunduzi AC, Yoon S, Bang S, Yang SH.   +5 more
europepmc   +1 more source

Therapeutic Potential of Berberis vulgaris in Modulating Metabolic Syndrome Biomarkers: Mechanistic Insights and Functional Food Implications

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Barberry (Berberis vulgaris) has emerged as a promising functional food candidate for the management of metabolic syndrome due to its diverse bioactive constituents, particularly berberine. This review synthesizes current experimental and clinical evidence regarding its effects on glycemic control, lipid metabolism, blood pressure regulation ...
Fakhar Shahid, Ifrah Jabeen, Muhammad Inam‐ur‐Raheem, Amin Mousavi Khaneghah, Muhammad Abid, Rana Muhammad Aadil   +5 more
wiley   +1 more source

Radiosynthesis and Evaluation of ¹⁸F‑Labeled Deuterated Radioligand for Positron Emission Tomography Imaging of Cholesterol 24-Hydroxylase. [PDF]

ACS Med Chem Lett
Li Y, Song Z, Shi H, Zhao T, Chen J, Zhou X, Hu Q, Li X, Meng L, Song R, Sun Z, Li C, Haider A, Yuan H, Liang SH.   +14 more
europepmc   +1 more source