Results 241 to 250 of about 105,966 (270)

Brain cholesterol homeostasis and its association with neurodegenerative diseases

Neurochemistry International, 2023
The brain is the most cholesterol-rich organ in mammals. However, cholesterol metabolism in the brain is completely independent of other tissues due to the presence of the blood-brain barrier (BBB). Neurons, astrocytes and oligodendrocytes are the main cells responsible for cholesterol synthesis in the brain.
Yi Gao, Wenjuan Tong, Shaowei Sun
exaly   +3 more sources

Cholesterol homeostasis in the developing brain: a possible new target for ethanol

Human & Experimental Toxicology, 2007
Cholesterol is an essential component of cell membranes and plays an important role in signal transduction. This brief overview presents evidence from the literature that ethanol may affect cholesterol homeostasis and that, in the developing brain, this may be involved in its developmental neurotoxicity.
GUIZZETTI M, COSTA, Lucio Guido
openaire   +4 more sources

Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline

Current Medicinal Chemistry, 2014
Cholesterol is one of the most important molecules in cell physiology because of its involvement in several biological processes: for instance, it determines both physical and biochemical properties of cell membranes and proteins. Disruption to cholesterol homeostasis leads to coronary heart disease, atherosclerosis and metabolic syndrome.
SEGATTO, MARCO, Leboffe, Loris, Trapani, Laura, Pallottini, Valentina   +3 more
core   +6 more sources

Hypoxia-Ischemia Brain Damage Disrupts Brain Cholesterol Homeostasis in Neonatal Rats

Neuropediatrics, 2009
The first 3 weeks of life is the peak time of oligodendrocytes development and also the critical period of cholesterol increasing dramatically in central nervous system in rats. Neonatal hypoxia-ischemia (HI) brain damage happening in this period may disturb the brain cholesterol balance as well as white matter development.To test this hypothesis ...
Z, Yu, S, Li, S H, Lv, H, Piao, Y H, Zhang, Y M, Zhang, H, Ma, J, Zhang, C K, Sun, A P, Li   +9 more
exaly   +3 more sources

Roles of glia cells in cholesterol homeostasis in the brain

Advances in Molecular and Cell Biology, 2003
Publisher Summary This chapter discusses that the brain is a cholesterol-rich organ, and increasing evidence suggests that cholesterol plays a number of key roles in the central nervous system (CNS) through regulation of membrane functions and by other mechanisms.
Jin-Ichi Itô
exaly   +2 more sources

Cholesterol homeostasis in the brain : importance of 24S-hydroxylation

, 1999
Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain.
Dieter Lütjohann (186632)
openaire   +2 more sources

Brain‐derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons

Journal of Cellular Physiology, 2018
In the central nervous system, cholesterol is critical to maintain membrane plasticity, cellular function, and synaptic integrity. In recent years, much attention was focused on the role of cholesterol in brain since a breakdown of cholesterol metabolism
Maria Stefania Spagnuolo, Aldo Donizetti, Lucia Iannotta   +2 more
exaly   +2 more sources

A Short‐Term Western Diet Impairs Cholesterol Homeostasis and Key Players of Beta Amyloid Metabolism in Brain of Middle Aged Rats [PDF]

Molecular Nutrition and Food Research, 2020
Scope: Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on brain cholesterol homeostasis, particularly at middle age, is unknown.
Maria Stefania Spagnuolo, Valentina Pallottini, Arianna Mazzoli   +2 more
exaly   +3 more sources

Brain cholesterol homeostasis in Wilson disease

Medical Hypotheses, 2013
Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism, resulting in pathological accumulation of Cu in many organs and tissues, predominantly in the liver and brain. There clearly is a close and complex relationship between Cu and the cholesterol's metabolic pathway; therefore any theory about the cholesterol ...
CACCIATORE, STEFANO, TENORI, LEONARDO
openaire   +3 more sources

TMET-05. LIPOPHAGY CONTROLS CHOLESTEROL HOMEOSTASIS AND BRAIN TUMOR GROWTH

Neuro-Oncology, 2023
Abstract Cholesterol is an essential structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels of membrane cholesterol, but with an abundant presence of cholesteryl ...
Feng Geng, Yaogang Zhong, Huali Su, Etienne Lefai, William Yong, Arnab Chakravarti, Deliang Guo   +6 more
openaire   +1 more source