Results 1 to 10 of about 12,470,437 (381)
Iron homeostasis imbalance and ferroptosis in brain diseases. [PDF]
MedComm (2020), 2023 Brain iron homeostasis is maintained through the normal function of blood–brain barrier and iron regulation at the systemic and cellular levels, which is fundamental to normal brain function.
Long H, Zhu W, Wei L, Zhao J.
europepmc +2 more sources
Role of Exosomes in Brain Diseases
Frontiers in Cellular Neuroscience, 2021 Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host
Nan Zhang +8 more
doaj +2 more sources
Applications of nanobodies in brain diseases. [PDF]
Front Immunol, 2022 Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeutic ...
Zheng F +6 more
europepmc +2 more sources
New Therapeutic Avenues of mCSF for Brain Diseases and Injuries
Frontiers in Cellular Neuroscience, 2018 Macrophage colony-stimulating factor (mCSF) is a cytokine known to promote the recruitment of macrophages inducing the release of CCL2, a chemokine mobilizing monocytes to sites of inflammation. Additionally, it induces microglia/macrophage proliferation
Vincent Pons, Serge Rivest
doaj +2 more sources
Use of neurofilament light chain to identify structural brain diseases in dogs [PDF]
Journal of Veterinary Internal MedicineBackground Neurofilament light chain (NfL) is released into the peripheral circulation by damaged axons. Objectives To evaluate the diagnostic value of serum NfL concentration in dogs with intracranial diseases. Animals Study included 37 healthy dogs, 31
Jookyung Sung +7 more
doaj +2 more sources
Pharmaceuticals, 2023 Drug delivery to the central nervous system (CNS) is limited due to the presence of the blood–brain barrier (BBB), a selective physiological barrier located at the brain microvessels that regulates the flow of cells, molecules and ions between the blood ...
M. Abdelsalam +4 more
semanticscholar +1 more source
Cytokine profiles in intensive care unit delirium [PDF]
Acute and Critical Care, 2022 Background Neuroinflammation causing disruption of the blood-brain barrier and immune cell extravasation into the brain parenchyma may cause delirium; however, knowledge of the exact pathophysiologic mechanism remains incomplete. The purpose of our study
Ryan J. Smith +5 more
doaj +1 more source
Nucleic acid drug vectors for diagnosis and treatment of brain diseases
Signal Transduction and Targeted Therapy, 2023 Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vectors are a decisive factor in therapeutic ...
Zhiguo Lu +7 more
semanticscholar +1 more source
Life, 2021 Neural stem cells (NSCs) are multipotent cells capable of self-renewal and differentiation into different nervous system cells. Mouse NSCs (mNSCs) are useful tools for studying neurogenesis and the therapeutic applications of neurodegenerative diseases ...
Yang Woo Kwon +4 more
doaj +1 more source
Self-healing hydrogel as an injectable implant: translation in brain diseases
Journal of Biomedical Sciences, 2023 Tissue engineering biomaterials are aimed to mimic natural tissue and promote new tissue formation for the treatment of impaired or diseased tissues. Highly porous biomaterial scaffolds are often used to carry cells or drugs to regenerate tissue-like ...
Junpeng Xu, S. Hsu
semanticscholar +1 more source