Results 1 to 10 of about 338,090 (265)

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies [PDF]

Advanced Science
Brain metabolism is uniquely regulated, and alterations in its metabolic networks often serve as critical drivers of the onset and progression of brain diseases.
Jingyi Zhou, Chen Jiang
doaj   +2 more sources

Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

Microbiome, 2021
Background Parkinson’s disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived from the gut microbiota, which has ...
Yan-fang Hou, Chang Shan, Si-yue Zhuang, Qian-qian Zhuang, Arijit Ghosh, Ke-cheng Zhu, Xiao-ke Kong, Shu-min Wang, Yan-ling Gong, Yu-ying Yang, Bei Tao, Li-hao Sun, Hong-Yan Zhao, Xing-zhi Guo, Wei-qing Wang, Guang Ning, Yan-yun Gu, Sheng-tian Li, Jian-min Liu   +18 more
doaj   +1 more source

The impact of metabolic overweight/obesity phenotypes on unplanned readmission risk in patients with COPD: a retrospective cohort study

Frontiers in Physiology, 2023
Background: There is an inconsistent association between overweight/obesity and chronic obstructive pulmonary disease (COPD). Considering that different metabolic characteristics exist among individuals in the same body mass index (BMI) category, the ...
Yang Tian, Yang Tian, Yang Tian, Yang Tian, Yang Tian, Luna Liu, Luna Liu, Luna Liu, Luna Liu, Luna Liu, Yuchen Li, Yuchen Li, Yuchen Li, Yuchen Li, Yuchen Li, Xiude Fan, Xiude Fan, Xiude Fan, Xiude Fan, Wanhong Wu, Wanhong Wu, Wanhong Wu, Wanhong Wu, Yingzhou Shi, Yingzhou Shi, Yingzhou Shi, Yingzhou Shi, Yingzhou Shi, Jie Jiang, Jie Jiang, Jie Jiang, Jie Jiang, Jie Jiang, Zinuo Yuan, Zinuo Yuan, Zinuo Yuan, Zinuo Yuan, Zinuo Yuan, Hang Dong, Hang Dong, Hang Dong, Hang Dong, Hang Dong, Huijie Li, Qiuhui Xuan, Qiuhui Xuan, Qiuhui Xuan, Qiuhui Xuan, Qiuhui Xuan, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu   +53 more
doaj   +1 more source

Osteocalcin ameliorates cognitive dysfunctions in a mouse model of Alzheimer’s Disease by reducing amyloid β burden and upregulating glycolysis in neuroglia

Cell Death Discovery, 2023
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by the accumulation of amyloid β peptides (Aβ) and impaired glucose metabolism in the brain.
Chang Shan, Deng Zhang, Dong-ni Ma, Yan-fang Hou, Qian-qian Zhuang, Yan-ling Gong, Li-hao Sun, Hong-yan Zhao, Bei Tao, Yu-ying Yang, Sheng-tian Li, Jian-min Liu   +11 more
doaj   +1 more source

Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

iScience, 2023
Summary: The hypothalamus, as a vital brain region for endocrine and metabolism regulation, undergoes functional disruption during obesity.The anti-aging effect of metformin has come into focus.
Leilei Yang, Peng Lu, Xiangyu Qi, Qian Yang, Luna Liu, Tao Dou, Qingbo Guan, Chunxiao Yu   +7 more
doaj   +1 more source

Biphasic Regulation of Caveolin-1 Gene Expression by Fluoxetine in Astrocytes: Opposite Effects of PI3K/AKT and MAPK/ERK Signaling Pathways on c-fos

Frontiers in Cellular Neuroscience, 2017
Previously, we reported that fluoxetine acts on 5-HT2B receptor and induces epidermal growth factor receptor (EGFR) transactivation in astrocytes. Recently, we have found that chronic treatment with fluoxetine regulates Caveolin-1 (Cav-1)/PTEN/PI3K/AKT ...
Baoman Li, Shu Jia, Tingting Yue, Li Yang, Chen Huang, Alexej Verkhratsky, Alexej Verkhratsky, Liang Peng   +7 more
doaj   +1 more source

Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

iScience, 2023
Summary: Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1Amut/-) and found that the mutant mice ...
Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu, Chao Xu, Zhao He, Yongfeng Song, Ling Gao, Shanshan Shao, Jiajun Zhao, Peng Lu   +11 more
doaj   +1 more source

Brain hypometabolism in rare genetic neurodegenerative disease: Niemann-Pick disease type C, spinocerebellar ataxia and Huntington disease assessed by FDG PET [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2021
Brain metabolic imaging using 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) with contemporaneous low-dose CT may be used to assess neurodegenerative diseases.
Yung Hsiang Kao, Melissa Cheng, Dennis Velakoulis, Mark Walterfang, Dinesh Sivaratnam   +4 more
doaj   +1 more source

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion

ASN Neuro, 2015
The epidermal growth factor receptor (EGFR) is linked to the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK 1/2 ) signaling pathways.
Jing Zhou, Ting Du, Baoman Li, Yan Rong, Alexei Verkhratsky, Liang Peng   +5 more
doaj   +1 more source

Integration between Glycolysis and Glutamate-Glutamine Cycle Flux May Explain Preferential Glycolytic Increase during Brain Activation, Requiring Glutamate

Frontiers in Integrative Neuroscience, 2017
The 1988 observation by Fox et al. (1988) that brief intense brain activation increases glycolysis (pyruvate formation from glucose) much more than oxidative metabolism has been abundantly confirmed.
Leif Hertz, Ye Chen
doaj   +1 more source