Results 11 to 20 of about 338,090 (265)
Brain JNK and metabolic disease [PDF]
Diabetologia, 2020 Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with central insulin and leptin resistance ...
Nogueiras, Rubén, Sabio, Guadalupe
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Brain Metabolic Alterations in Alzheimer’s Disease
International Journal of Molecular Sciences, 2022 The brain is one of the most energy-consuming organs in the body. Satisfying such energy demand requires compartmentalized, cell-specific metabolic processes, known to be complementary and intimately coupled. Thus, the brain relies on thoroughly orchestrated energy-obtaining agents, processes and molecular features, such as the neurovascular unit, the ...
Carlos G. Ardanaz +2 more
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Metabolic profiling of Alzheimer's disease brains [PDF]
Scientific Reports, 2013 AbstractAlzheimer's disease (AD) is an irreversible, progressive brain disease and can be definitively diagnosed after death through an examination of senile plaques and neurofibrillary tangles in several brain regions. It is to be expected that changes in the concentration and/or localization of low-molecular-weight molecules are linked to the ...
Inoue, Koichi +6 more
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Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease [PDF]
Frontiers in Neuroscience, 2021 Alzheimer’s disease (AD) is the most common form of age-related dementia. Despite decades of research, the etiology and pathogenesis of AD are not well understood. Brain glucose hypometabolism has long been recognized as a prominent anomaly that occurs in the preclinical stage of AD.
Xin Zhang +3 more
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Brain cholesterol metabolism and Parkinson's disease [PDF]
Movement Disorders, 2019 ABSTRACTBackgroundCirculating cholesterol levels have been linked to PD, but not directly to brain physiology.ObjectiveTo assess whether brain cholesterol metabolism is related to PD.MethodsSixty PD patients and 64 controls were recruited from an academic movement disorder clinic (2009–2012).
Xuemei Huang +11 more
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Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases
CNS Neuroscience & Therapeutics, 2022 AbstractAstrocytes are the most abundant cells in the brain. They have many important functions in the central nervous system (CNS), including the maintenance of glutamate and ion homeostasis, the elimination of oxidative stress, energy storage in glycogen, tissue repair, regulating synaptic activity by releasing neurotransmitters, and participating in
Zhenlei Chen +6 more
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Brain Glucose Metabolism in Alzheimer’s Disease
The American Journal of the Medical Sciences, 1994 In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer's disease showed a marked decrease when compared with nondemented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-dependent decline in the rate of glucose use. These data
R, Swerdlow +5 more
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ASN Neuro, 2014 This study investigates the role of the intracellular adenosine transporter equilibrative nucleoside transporter 3 (ENT3) in stimulated release of the gliotransmitter adenosine triphosphate (ATP) from astrocytes.
Dan Song +5 more
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Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
Molecular Brain, 2019 It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose ...
Chang Shan +6 more
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Brain fuel metabolism, aging, and Alzheimer’s disease [PDF]
Nutrition, 2011 Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer's disease--carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism ...
Cunnane, Stephen +16 more
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