Results 21 to 30 of about 338,090 (265)
Frontiers in Molecular Neuroscience, 2018 Osteoblasts derived osteocalcin (OCN) is recently reported to be involved in dopaminergic neuronal development. As dopaminergic neuronal injury in the substantia nigra (SN) is a pathological hallmark of Parkinson’s disease (PD), we investigated whether ...
Xing-zhi Guo +9 more
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Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases
Neurobiology of Disease, 2022 Glial cells are the most abundant cells of the brain, outnumbering neurons. These multifunctional cells are crucial for maintaining brain homeostasis by providing trophic and nutritional support to neurons, sculpting synapses, and providing an immune ...
Ruqayya Afridi +2 more
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Sphingolipid metabolism in brain insulin resistance and neurological diseases
Frontiers in Endocrinology, 2023 Sphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence,
Meng Mei +4 more
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Clinical and Translational Medicine, 2022 Background Targeted drugs have greatly improved the therapeutic outcome of non‐small cell lung cancer (NSCLC) patients compared with conventional chemotherapy, whereas about one‐third of patients are so far not suitable for targeted therapy due to lack ...
Qianqian Wang +10 more
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The landscape of metabolic brain alterations in Alzheimer’s disease [PDF]
Alzheimer's & Dementia, 2021 AbstractINTRODUCTIONAlzheimer’s disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes in brain has been missing.METHODSWe metabolically profiled 500 samples from the dorsolateral prefrontal cortex.
Richa Batra +12 more
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Alzheimer's Disease: Metabolic Uncoupling of Associative Brain Regions [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1986 Abstract:Evidence indicates that Alzheimer's disease (AD) causes functional disconnection of neocortical association areas. In mildly demented AD patients without measurable neocortically-mediated cognitive abnormalities, positron emission tomography demonstrates reduced parietal lobe glucose metabolism and left/right metabolic asymmetries in ...
S. I. RAPOPORT +3 more
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Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation
Frontiers in Physiology, 2020 It is well known that exposure to microgravity in astronauts leads to a plethora physiological responses such as headward fluid shift, body unloading, and cardiovascular deconditioning.
Marc Kermorgant +10 more
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Biology, 2017 The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released transmitter glutamate/GABA to neurons after astrocytic uptake.
Leif Hertz, Douglas L Rothman
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Translational Psychiatry, 2023 s Metabolic syndrome (MetS) is characterized by a constellation of metabolic risk factors, including obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) levels, hypertension, and hyperglycemia, and is associated with stroke and ...
Chenye Shen, Chaoqiang Liu, Anqi Qiu
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Molecular Genetics & Genomic Medicine, 2020 Background Biallelic pathogenic variants in CBS gene cause the most common form of homocystinuria, the classical homocystinuria (HCU). The worldwide prevalence of HCU is estimated to be 0.82:100,000 [95% CI, 0.39–1.73:100,000] according to clinical ...
Giovana R. Weber Hoss +3 more
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