Results 41 to 50 of about 338,090 (265)

The relationship between adult phenylketonuria and the cardiovascular system - insights into mechanisms and risks

Orphanet Journal of Rare Diseases
Studies in adults with PKU have mainly focused on the neuropsychiatric complications that may arise in individuals who are unable to maintain the recommended lifetime diet. Some recent epidemiological studies suggest to consider other complications.
Yann Dos Santos, Friedrich Trefz, Maria Giżewska, Annemiek M.J. van Wegberg, Bruno Lefort, François Labarthe, Francjan van Spronsen, François Maillot   +7 more
doaj   +1 more source

Ceramide signalling in inherited and multifactorial brain metabolic diseases

Neurobiology of Disease, 2020
In recent years, research on sphingolipids, particularly ceramides, has attracted increased attention, revealing the important roles and many functions of these molecules in several human neurological disorders.
Devesh C. Pant, Sergio Aguilera-Albesa, Aurora Pujol   +2 more
doaj   +1 more source

Peripheral and cognitive benefits of physical exercise in a mouse model of midlife metabolic syndrome

Scientific Reports, 2022
Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population.
Farida El Gaamouch, Hsiao-yun Lin, Qian Wang, Wei Zhao, Jiangping Pan, Kalena Liu, Jean Wong, Clark Wu, Chongzhen Yuan, Haoxiang Cheng, Weiping Qin, Ke Hao, Bin Zhang, Jun Wang   +13 more
doaj   +1 more source

Energy metabolism in childhood neurodevelopmental disorders

EBioMedicine, 2021
Whereas energy function in the aging brain and their related neurodegenerative diseases has been explored in some detail, there is limited knowledge about molecular mechanisms and brain networks of energy metabolism during infancy and childhood.
Oyarzábal A, Musokhranova U, Barros LF, García-Cazorla A   +3 more
doaj   +1 more source

Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia [PDF]

Alzheimer's & Dementia, 2008
BackgroundFew comparative studies exist of metabolic brain changes among neurodegenerative illnesses. We compared brain metabolic abnormalities in Alzheimer's disease (AD) and in Parkinson's disease with dementia (PDD) as measured by proton magnetic resonance spectroscopy (MRS).MethodsTwelve patients with idiopathic PDD, 22 patients with probable mild ...
H Randall, Griffith, Jan A, den Hollander, Ozioma C, Okonkwo, Timothy, O'Brien, Ray L, Watts, Daniel C, Marson   +5 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Risk factors for early readmission to hospital in patients with malignancy-related ascites: a retrospective cohort study

Frontiers in Oncology
IntroductionMalignancy-related ascites (MRA) is a common serious complication of many advanced malignant tumors with high morbidity and mortality. The high hospital expenditures induced by unplanned readmission in patients with MRA have become an urgent ...
Zhenhua Tian, Zhenhua Tian, Zhenhua Tian, Zhenhua Tian, Zhenhua Tian, Zhilong Huang, Yaqi Guo, Yaqi Guo, Yaqi Guo, Yaqi Guo, Xiaolin Zhao, Xiaolin Zhao, Xiaolin Zhao, Xiaolin Zhao, Luna Liu, Luna Liu, Luna Liu, Luna Liu, Luna Liu, Chunxiao Yu, Chunxiao Yu, Chunxiao Yu, Chunxiao Yu, Chunxiao Yu, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan   +28 more
doaj   +1 more source

Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases [version 1; peer review: 2 approved]

F1000Research, 2020
The brain undergoes two aging programs: chronological and endocrinological. This is particularly evident in the female brain, which undergoes programs of aging associated with reproductive competency.
Yiwei Wang, Aarti Mishra, Roberta Diaz Brinton   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source