Results 11 to 20 of about 12,998,191 (376)
tRNA Modifications and Dysregulation: Implications for Brain Diseases. [PDF]
Brain SciTransfer RNAs (tRNAs) are well-known for their essential function in protein synthesis. Recent research has revealed a diverse range of chemical modifications that tRNAs undergo, which are crucial for various cellular processes.
Lv X, Zhang R, Li S, Jin X.
europepmc +2 more sources
Pharmaceuticals, 2023 Drug delivery to the central nervous system (CNS) is limited due to the presence of the blood–brain barrier (BBB), a selective physiological barrier located at the brain microvessels that regulates the flow of cells, molecules and ions between the blood ...
M. Abdelsalam +4 more
semanticscholar +1 more source
Iron homeostasis imbalance and ferroptosis in brain diseases
MedComm, 2023 Brain iron homeostasis is maintained through the normal function of blood–brain barrier and iron regulation at the systemic and cellular levels, which is fundamental to normal brain function.
Haining Long +3 more
semanticscholar +1 more source
Nucleic acid drug vectors for diagnosis and treatment of brain diseases
Signal Transduction and Targeted Therapy, 2023 Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vectors are a decisive factor in therapeutic ...
Zhiguo Lu +7 more
semanticscholar +1 more source
Self-healing hydrogel as an injectable implant: translation in brain diseases
Journal of Biomedical Sciences, 2023 Tissue engineering biomaterials are aimed to mimic natural tissue and promote new tissue formation for the treatment of impaired or diseased tissues. Highly porous biomaterial scaffolds are often used to carry cells or drugs to regenerate tissue-like ...
Junpeng Xu, S. Hsu
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Biomedicines, 2023 Increasingly prevalent acute and chronic human brain diseases are scourges for the elderly. Besides the lack of therapies, these ailments share a neuroinflammation that is triggered/sustained by different innate immunity-related protein oligomers called ...
A. Chiarini +4 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2023 Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS).
O. Semyachkina-Glushkovskaya +12 more
semanticscholar +1 more source
MIF contribution to progressive brain diseases. [PDF]
J NeuroinflammationProgressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies.
Matejuk A +5 more
europepmc +2 more sources
A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
PLoS Biology, 2023 Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of disease risk genes provide a molecular-based signature, based on ...
Y. Zeighami +9 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2023 Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system.
T. Numakawa, Ryutaro Kajihara
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