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Determination of Tight Junction Integrity in Brain Endothelial Cells Based on Tight Junction Protein Expression. [PDF]
Methods Mol BiolAlluri H, Peddaboina CS, Tharakan B.
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iPS Cell Differentiation into Brain Microvascular Endothelial Cells
2022The blood-brain barrier is a tissue structure that modulates the selective entry of molecules into the brain compartment. This barrier offers protection to the brain microenvironment from toxins or any fluctuations in the composition of the blood plasma via a layer of endothelial cells connected by tight junctions and supported by pericytes and ...
Angelica, Medina, Hengli, Tang
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Endothelial Cell Swelling and Brain Perfusion
The Journal of Trauma: Injury, Infection, and Critical Care, 1997Whereas the contribution of glial swelling to no-reflow conditions in the ischemic penumbra or during reperfusion after after global ischemia is widely discussed, little is known about cell volume control of endothelial cells under reperfusion conditions.The effect of extracellular acidosis-a key mediator of secondary brain damage-on cell volume was ...
O, Kempski, S, Behmanesh
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Brain Endothelial Cells as Pharmacological Targets in Brain Tumors
Molecular Neurobiology, 2004The blood-brain barrier contributes to brain homeostasis by controlling the access of nutrients and toxic substances to the central nervous system (CNS). The acquired brain endothelial cells phenotype results from their sustained interactions with their microenvironment.
Michel, Demeule +5 more
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Ca2+ homeostasis in brain microvascular endothelial cells
2021Blood brain barrier (BBB) is formed by the brain microvascular endothelial cells (BMVECs) lining the wall of brain capillaries. Its integrity is regulated by multiple mechanisms, including up/downregulation of tight junction proteins or adhesion molecules, altered Ca2+ homeostasis, remodeling of cytoskeleton, that are confined at the level of BMVECs ...
Roberta, Stoica +5 more
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Lipid Polarity in Brain Capillary Endothelial Cells
Endothelium, 2001Brain capillary endothelial cells (BCEC) represent an epithelial like cell type with continuous tight junctions and polar distributed proteins. In this paper we investigated whether cultured BCEC show a polar distribution of membrane lipids as this was demonstrated for many epithelial cell types. Therefore we applied a high yield membrane fractionation
B J, Tewes, H J, Galla
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Brain microvessel endothelial cell culture systems
1996The cellular basis of the blood-brain barrier (BBB) was defined as the endothelial lining of the brain microvessels in the late 1960s (Reese and Karnovsky, 1967; Brightman and Reese, 1969). This unique endothelial lining was recognized as the sole restrictive permeability barrier to the passage of nutrients, drugs, and metabolic waste products between ...
K L, Audus +3 more
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Lamotrigine is a substrate for OCT1 in brain endothelial cells
Biochemical Pharmacology, 2012The mechanisms that underpin the passage of lamotrigine at the blood-brain barrier to its site of action in the brain is poorly understood. Lamotrigine has been postulated to be delivered to its site of action in the brain favourably despite its physicochemical properties.
Dickens, David +8 more
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