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Postnatal mitotic division of endothelial cells in the brain

Neuroscience Research, 1986
Ultrastructural details of capillary endothelial cells undergoing mitosis in the central nervous system are reported. These mitotic endothelial cells were seen in the brain of 10-day-old mice treated with 6-aminonicotinamide, an antagonist of niacin. Electron microscopy revealed these cells to be characterized by segregated chromosomal materials and ...
H, Aikawa, K, Suzuki
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Regulation of motility in bovine brain endothelial cells

Journal of Cellular Physiology, 1991
AbstractScatter factor (SF) is a fibroblast‐derived cytokine which stimulates motility of epithelial and vascular endothelial cells. We used a quantitative assay based on migration of cells from microcarrier beads to flat surfaces to study the regulation of motility in bovine brain endothelial cells (BBEC). Peptide growth factors (EGF, ECGF, basic FGF)
E M, Rosen   +6 more
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Brain endothelial cells and the glio-vascular complex

Cell and Tissue Research, 2008
We present and discuss the role of endothelial and astroglial cells in managing the blood-brain barrier (BBB) and aspects of pathological alterations in the BBB. The impact of astrocytes, pericytes, and perivascular cells on the induction and maintenance of the gliovascular unit is largely unidentified so far. An understanding of the signaling pathways
Hartwig, Wolburg   +4 more
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Signaling the brain in inflammation: the role of endothelial cells

Frontiers in Bioscience, 2004
Peripheral inflammation signals the brain primarily via blood-borne proinflammatory cytokines, released from activated immune cells. In addition to these cytokines, immune-brain signaling is known to involve another key mediator, prostaglandin E2 (PGE2), the level of which is elevated in the brain during various inflammatory states and which acts to ...
Kiyoshi, Matsumura, Shigeo, Kobayashi
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Purification of Endothelial Cells from Rat Brain

2014
Endothelial cells make up a minor population of cells in a tissue, but play a major role in tissue homeostasis, as well as in diverse pathologies. To understand the biology of cerebral endothelium, purification and characterization of the cerebrocortical endothelial cell population is highly desirable.
Jinhua, Luo   +5 more
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Tricellulin expression in brain endothelial and neural cells

Cell and Tissue Research, 2012
Tricellulin is a tight junction (TJ) protein, which is not only concentrated at tricellular contacts but also present at bicellular contacts between epithelial tissues. We scrutinized the brain for tricellulin expression in endothelial and neural cells by using real-time polymerase chain reaction, Western blot and immunohistochemical and ...
Cibelle, Mariano   +11 more
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NG2 immunoreactivity on human brain endothelial cells

Acta Neuropathologica, 2001
In this study, we evaluated the expression of NG2 on human brain endothelial cells derived from temporal lobe tissue resected as a treatment for intractable epilepsy. Using dissociated cell cultures, we found expression of NG2 on both proliferating and non-proliferating cells, at the mRNA level by reverse transcription-polymerase chain reaction ...
S, Pouly   +4 more
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Morphology and Properties of Brain Endothelial Cells

2010
The molecular advances in various aspects of brain endothelial cell function in steady states are considerable and difficult to summarize in one chapter. Therefore, this chapter focuses on endothelial permeability mechanisms in steady states and disease namely vasogenic edema.
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Endothelial cells in the context of brain arteriovenous malformations

Journal of Clinical Neuroscience, 2011
A subset of brain arteriovenous malformations (AVM) cannot be treated using today's treatment paradigms. Novel therapies may be developed, however, as the underlying pathophysiology of these lesions becomes better understood. Endothelial cells (EC) are the subject of new biological therapies, such as radiosensitisation and vascular targeting. This work
Vanessa, Sammons   +3 more
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Brain Endothelial Cells, Atherosclerosis and Thromboembolism

Cerebrovascular Diseases, 2010
Our studies describe the in vitro effects of nerve growth factor (NGF) on brain endothelial cells in tissue culture in provoking changes in transducing and transcription factors and the upregulation of the appropriate gene for NGF, namely, trk A. In addition, a novel new protein is secreted into the culture media; this protein has a molecular weight of
F.M. Yatsu, R. Alam, S.S. Alam, G. Bui
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