Results 11 to 20 of about 2,811,049 (348)
Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies.
Biochemistry & Pharmacology Open Access, 2016 Ischemia-reperfusion injury is a common feature of ischemic stroke, which occurs when blood supply is restored after a period of ischemia. Reperfusion can be achieved either by thrombolysis using thrombolytic reagents such as tissue plasminogen activator
Lin L, W. X, Yu Z
semanticscholar +2 more sources
Propofol Pretreatment Protects Hippocampal CA1 Neurons from Ischemia-reperfusion Injury in Rat
Otorhinolaryngology and Facial Plastic Surgery, 2023 Background: The number of brain strokes induced by ischemia has increased significantly in recent years as a result of brain vascular disorders. Some of these patients will require brain vascular surgery.
Delaram Farhangi +3 more
doaj +1 more source
Top ten discoveries of the year: Neurovascular disease
Free Neuropathology, 2020 The aim of this review is to highlight novel findings in 2019 in the area of neurovascular disease. Experimental studies have provided insight into disease development, molecular determinants of pathology, and putative novel therapeutic targets.
Anna Maria Planas
doaj +1 more source
Cell Reports, 2020 Summary: Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c+ cells, but their phenotype, origin, and functions remain largely unknown.
Mattia Gallizioli +16 more
doaj +1 more source
The correlation between patent foramen ovale and brain ischemia in plateau residents
BMC Cardiovascular Disorders, 2021 Background It has been suggested that patent foramen ovale (PFO) contributes to the majority of cryptogenic stroke cases in young people, however, the direct link is still undetermined.
Gang Liu +5 more
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Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia
Journal of Neuroinflammation, 2020 Background Recent findings describe microglia as modulators of neurogenesis in the subventricular zone (SVZ). SVZ microglia in the adult rat are thought to adopt a neurotrophic phenotype after ischemic stroke.
Urs Fisch +4 more
doaj +1 more source
Frontiers in Physiology, 2020 Oxidative stress and inflammation are two critical pathological processes of cerebral ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and therapeutic target triggering both oxidative stress and neuroinflammation in ...
Shuang Chen +3 more
semanticscholar +1 more source
The neuroprotective effects of intramuscular insulin-like growth factor-I treatment in brain ischemic rats. [PDF]
PLoS ONE, 2013 Brain ischemia leads to muscle inactivity-induced atrophy and may exacerbate motor function deficits. Intramuscular insulin-like growth factor I (IGF-I) injection has been shown to alleviate the brain ischemia-induced muscle atrophy and thus improve the ...
Heng-Chih Chang +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells.
R. Pluta +3 more
semanticscholar +1 more source
Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]
, 2017 Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P +11 more
core +1 more source