Results 131 to 140 of about 2,926,291 (344)

Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study

BMC Cancer, 2019
Background Non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations often develop brain metastases. Treatment with EGFR-tyrosine kinase inhibitors (TKIs) has shown the effectiveness; however, knowledge of ...
Yung-Hsuan Chen, Yen-Fu Chen, Chung-Yu Chen, Jin-Yuan Shih, Chong-Jen Yu   +4 more
doaj   +1 more source

A systematic review of evidence on malignant spinal metastases : natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression [PDF]

, 2013
Background: Spinal metastases can lead to significant morbidity and reduction in quality of life due to spinal cord compression (SCC). Between 5% and 20% of patients with spinal metastases develop metastatic spinal cord compression during the course of ...
M Connock, D Shyangdan, Shyangdan, D., Court, Rachel A., Kandala, Ngianga-Bakwin, P Sutcliffe, R Court, N-B Kandala, Sutcliffe, P. (Paul), Connock, M., A Clarke, Clarke, Aileen   +11 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Platinum Sensitivity as an Independent Prognostic Factor in Patients with Brain Metastases from Ovarian Carcinoma

Middle East Journal of Cancer, 2011
Background: The brain is a rare site of metastases from ovarian cancer. Limited data are available on prognostic factors, standard treatment, and survival.
John Windara Green, Rosemary Lord, Julie O’Hagan, Khizar Hayat, Helen Wong, Faisal Azam   +5 more
doaj  

TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases

Journal of Clinical Oncology, 2019
PURPOSE Evidence-based treatments for metastatic, human epidermal growth factor receptor 2 (HER2)–positive breast cancer to the CNS are limited. We previously reported modest activity of neratinib monotherapy for HER2-positive breast cancer brain ...
R. Freedman, R. Gelman, C. Anders, M. Melisko, H. Parsons, Anne Cropp, Kelly Silvestri, C. Cotter, K. Componeschi, Juan M. Marte, R. Connolly, B. Moy, C. V. Van Poznak, K. Blackwell, S. Puhalla, R. Jankowitz, K. Smith, N. Ibrahim, T. Moynihan, C. O'Sullivan, J. Nangia, P. Niravath, N. Tung, P. Pohlmann, Robyn Burns, M. Rimawi, I. Krop, A. Wolff, E. Winer, N. Lin   +29 more
semanticscholar   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

Cancer Discovery, 2019
There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBMs). Thus, we performed RNA-sequencing (RNA-seq) on 88 resected MBMs and 42 patient-matched extracranial metastases (ECMs); tumors with sufficient ...
Grant M Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, J. McQuade, L. Haydu, Aron Y Joon, A. Reuben, M. P. de Macedo, F. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, A. Sreekumar, C. Hudgens, Barbara G. Knighton, W. Deng, S. Ferguson, H. Tawbi, I. Glitza, J. Gershenwald, Y. V. Vashisht Gopal, P. Hwu, J. Huse, J. Wargo, P. A. Futreal, N. Putluri, A. Lazar, R. Deberardinis, J. Marszalek, Jianjun Zhang, S. Holmen, M. Tetzlaff, M. Davies   +33 more
semanticscholar   +1 more source

Emerging role of brain metastases in the prognosis of breast cancer patients

, 2011
Amanda Hambrecht1,2, Rahul Jandial2, Josh Neman21Department of Biology, University of Southern California; 2Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, CA, USAAbstract: Cancer starts with one rogue cell ...
Neman J, Jandial R, Hambrecht A
core  

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Brain Metastases from Ovarian Carcinoma

, 2011
This paper will focus on knowledge related to brain metastases from ovarian carcinoma. So far, less than 600 cases were documented in the literature with an incidence among ovarian carcinoma patients ranging from 0.29% to 11.6%. The ovarian carcinoma was
Benjamin Piura, Ettie Piura
core   +1 more source