Results 171 to 180 of about 2,926,291 (344)

Patterns of CNS metastases in breast cancer patients

, 2016
In den letzten Jahren wurde eine steigende Inzidenz der ZNS-Metastasen beim Mammakarzinom verzeichnet. Diese sind ein limitierender Faktor für die Lebensqualität betroffener Patientinnen und mit einer eingeschränkten Prognose verbunden.
Scriba, Verena
core  

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?

, 2018
An estimated 20% of patients with cancer will develop brain metastases. Approximately 200,000 individuals in the United States alone receive whole-brain radiotherapy (WBRT) each year to treat brain metastases.
Jeffrey S. Wefel, Paul D. Brown, Anthony L. Asher, Manmeet S. Ahluwalia, Vinai Gondi, Osaama H. Khan   +5 more
core   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Joint EANM/EANO/RANO/SNMMI practice guideline/procedure standard for PET imaging of brain metastases: version 1.0 [PDF]

This joint practice guideline/procedure standard was collaboratively developed by the European Association of Nuclear Medicine (EANM), the Society of Nuclear Medicine and Molecular Imaging (SNMMI), the European Association of Neuro-Oncology (EANO), and ...
Law, Ian, Tolboom, Nelleke, Bent, M. J.Van den, Short, Susan C., Le Rhun, Emilie, Galldiks, Norbert, Johnson, Derek R., Weehaeghe, Donatienne Van, Verger, Antoine, Huang, Raymond Y., Furtner, Julia, Cicone, Francesco, Guedj, Eric, Vogelbaum, Michael A., Wen, Patrick Y., Gempt, Jens, Albert, Nathalie L., Preusser, Matthias, Chang, Susan M.   +18 more
core  

Bona Fide Intersegmental Plane Hepatectomy Along the Glissonean Branches (BIPHG)

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT This review traces the author's personal journey over three decades in the evolution of liver resection techniques, culminating in the proposal of the Bona Fide Intersegmental Plane Hepatectomy Along Glissonean Branches (BIPHG). Beginning with pioneering experiences in laparoscopic and robotic liver surgeries, the author highlights key ...
Go Wakabayashi, Taiga Wakabayashi
wiley   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Analysis of prognostic factors in 352 lung cancer patients with brain metastases

Chinese Journal of Lung Cancer, 2008
Background and Objective Lung cancer has become one of the most common malignant tumors in China. The prognosis of lung cancer is poor mainly because of relapse and distant metastases and brain metastasis occurs frequently.
Hao BAI, Baohui HAN
doaj