Results 141 to 150 of about 26,410 (296)
Advanced Science, EarlyView.Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu +9 more
wiley +1 more source
Advanced Science, EarlyView.In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun +13 more
wiley +1 more source
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
Advanced Science, EarlyView.This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu +6 more
wiley +1 more source
Pluripotent stem cells-based neural organoids for modelling human brain development and diseases
Cell & BioscienceBrain organoids have emerged as transformative in vitro models for studying human neurodevelopment, neural disorders, and evolutionary brain complexity. This review systematically compares neural development in mice and humans, reflecting the limitations
Lingling Tong +10 more
doaj +1 more source
Bioengineering of brain organoids
, 2023 Understanding the human brain is an exciting challenge in particular for scientists. Studying the behavior of the human brain can lead to understanding the causes of several diseases and delineate a path to find possible cures. The use of animal models has helped scientist historically to meet these goals; however, there are important differences ...
openaire +1 more source
Advanced Science, EarlyView.This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu +7 more
wiley +1 more source
Microglia-containing neural organoids as brain microphysiological systems for long-term culture
Frontiers in Cellular NeuroscienceMicroglia, essential for brain development, homeostasis, and neuroinflammation, originate from the yolk sac during embryogenesis and migrate into the developing brain.
Alex Rittenhouse +7 more
doaj +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source