Results 11 to 20 of about 379,210 (125)

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Molecular Autism, 2020
Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder.
Shreya Das Sharma, Rakhi Pal, Bharath Kumar Reddy, Bhuvaneish T. Selvaraj, Nisha Raj, Krishna Kumar Samaga, Durga J. Srinivasan, Loren Ornelas, Dhruv Sareen, Matthew R. Livesey, Gary J. Bassell, Clive N. Svendsen, Peter C. Kind, Siddharthan Chandran, Sumantra Chattarji, David J. A. Wyllie   +15 more
doaj   +1 more source

The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage

Brain Sciences, 2023
Perinatal brain damage, one of the most common causes of lifelong impairment, is predominantly caused by a lack of oxygen and glucose during early development.
Denis Jagečić, Dražen Juraj Petrović, Iva Šimunić, Jasmina Isaković, Dinko Mitrečić   +4 more
doaj   +1 more source

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP

Molecular Brain, 2019
Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute, Sarayu Ramakrishna, Nagammal Neelagandan, Sumantra Chattarji, Ravi. S. Muddashetty   +4 more
doaj   +1 more source

Enhanced cultivation of chicken primordial germ cells

Scientific Reports, 2023
The cultivation and expansion of chicken primordial germ cells (cPGCs) are of critical importance for both biotechnological applications and the management of poultry genetic biodiversity.
Nima Dehdilani, Sara Yousefi Taemeh, Sylvie Rival-Gervier, Guillaume Montillet, Clémence Kress, Christian Jean, Lena Goshayeshi, Hesam Dehghani, Bertrand Pain   +8 more
doaj   +1 more source

Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

Stem Cell Research & Therapy, 2020
Background Retinal and/or optic nerve injury is one of the leading causes of blindness due to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress this neurodegeneration.
Seyedeh-Zahra Seyedrazizadeh, Sara Poosti, Abdoreza Nazari, Mehdi Alikhani, Faezeh Shekari, Farzad Pakdel, Koorosh Shahpasand, Leila Satarian, Hossein Baharvand   +8 more
doaj   +1 more source

Specific frontal neural dynamics contribute to decisions to check

Nature Communications, 2016
Information seeking is thought to rely on the brain's frontal cortex but which regions specifically control this drive remains unknown. Here the authors show that monkeys deciding to seek information on the current state of the environment showed ...
Frederic M. Stoll, Vincent Fontanier, Emmanuel Procyk   +2 more
doaj   +1 more source

Retinotopy Inspired Brain Encoding Model and the All-for-One Training Recipe [PDF]

arXiv, 2023
Brain encoding models aim to predict brain voxel-wise responses to stimuli images, replicating brain signals captured by neuroimaging techniques. There is a large volume of publicly available data, but training a comprehensive brain encoding model is challenging.
arxiv  

NMDAR mediated dynamic changes in m6A inversely correlates with neuronal translation

Scientific Reports, 2022
Epitranscriptome modifications are crucial in translation regulation and essential for maintaining cellular homeostasis. N6 methyladenosine (m6A) is one of the most abundant and well-conserved epitranscriptome modifications, which is known to play a ...
Naveen Kumar Chandappa Gowda, Bharti Nawalpuri, Sarayu Ramakrishna, Vishwaja Jhaveri, Ravi S. Muddashetty   +4 more
doaj   +1 more source

The mechanics of human brain organoids [PDF]

Phys. Rev. E 101, 022403 (2020), 2018
Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs morphogenesis and, in particular, the early morphogenesis of the cortex.
arxiv   +1 more source

Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting

Cell Reports, 2021
Summary: For precise motor control, distinct subpopulations of corticospinal neurons (CSN) must extend axons to distinct spinal segments, from proximal targets in the brainstem and cervical cord to distal targets in thoracic and lumbar spinal segments ...
Vibhu Sahni, Sara J. Shnider, Denis Jabaudon, Janet H.T. Song, Yasuhiro Itoh, Luciano C. Greig, Jeffrey D. Macklis   +6 more
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