Results 21 to 30 of about 919,937 (353)
Archives of Neurology, 2008 Mutations that cause autosomal recessive primary microcephaly (MCPH), including MCPH1 through MCPH6, have provided insight into the normal programming that directs brain growth and defines ultimate brain size. The common denominator in these mutations is that they all manifest within neural stem and progenitor cells, decreasing their numbers at various
openaire +2 more sources
Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. [PDF]
, 2015 We have recently shown that Natural Killer (NK) cells control survival and differentiation of Cancer Stem-like Cells (CSCs) through two distinct phenotypes of cytotoxic and anergic NK cells, respectively. In this report, brain CSCs and their serum and NK
Bui, Vickie T +6 more
core +1 more source
INRAE Productions Animales, 2023 Le cerveau est un organe complexe et tout modèle pour l'étudier dans ses aspects normaux et pathologiques devient un outil de choix en neurobiologie. La maîtrise et la diffusion de protocoles permettant le développement d'organoïdes cérébraux ont ouvert
Bertrand PAIN +4 more
doaj +1 more source
Frontiers in Neurorobotics, 2014 One of the principal functions of human language is to allow people to coordinate joint action. This includes the description of events, requests for action, and their organization in time.
Xavier eHinaut +8 more
doaj +1 more source
Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]
, 2018 Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po +13 more
core +9 more sources
Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
Nature Communications, 2016 Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus ...
Noriyuki Kishi +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 The orderly radial migration of cortical neurons from their birthplace in the germinal zones to their final destination in the cortical plate is a prerequisite for the functional assembly of microcircuits in the neocortex.
Veronique Cortay +11 more
doaj +1 more source
NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP
Molecular Brain, 2019 Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute +4 more
doaj +1 more source
Molecular Autism, 2020 Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder.
Shreya Das Sharma +15 more
doaj +1 more source
Brain Sciences, 2023 Perinatal brain damage, one of the most common causes of lifelong impairment, is predominantly caused by a lack of oxygen and glucose during early development.
Denis Jagečić +4 more
doaj +1 more source