Results 21 to 30 of about 933,949 (357)

The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage

Brain Sciences, 2023
Perinatal brain damage, one of the most common causes of lifelong impairment, is predominantly caused by a lack of oxygen and glucose during early development.
Denis Jagečić, Dražen Juraj Petrović, Iva Šimunić, Jasmina Isaković, Dinko Mitrečić   +4 more
doaj   +1 more source

Disease-specific, neurosphere-derived cells as models for brain disorders [PDF]

, 2010
There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses.
Abrahamsen, G., An, J., Anderson, M., Beckhouse, A.G., Bellette, B., Bennebroek, M., Cecil, R., Chalk, A.M., Cochrane, J., Cook, A.L., Fan, Y., Féron, F., Mackay-Sim, A., Mahler, S., Matigian, N., McCurdy, R., McGrath, J.J., Mellick, G.D., Murrell, W., Nouwens, A., Perry, C., Raju, J., Ravishankar, S., Silburn, P.A., Sue, C.M., Sutharsan, R., Sutherland, G.T., Vitale, A.M., Wells, C.A., Wood, S.A.   +29 more
core   +1 more source

How to build a brain [PDF]

, 2014
Your cells are magnificent little things, every single one is full of complex microsystems all working together to keep you going. They’re more intricate and advanced than any machines we can make, but sometimes… they need a little help to get going ...
Bruggeman, Kiara
core   +1 more source

NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells

Stem Cell Reports, 2018
Summary: Somatic reprogramming, which was first identified in rodents, remains poorly described in non-mammalian species. Here, we generated avian reprogrammed cells by reprogramming of chicken and duck primary embryonic fibroblasts.
Aurélie Fuet, Guillaume Montillet, Christian Jean, Pauline Aubel, Clémence Kress, Sylvie Rival-Gervier, Bertrand Pain   +6 more
doaj   +1 more source

Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes

Cell Reports, 2023
Summary: Investigation of translation in rare cell types or subcellular contexts is challenging due to large input requirements for standard approaches. Here, we present “nanoRibo-seq” an optimized approach using 102- to 103-fold less input material than
John E. Froberg, Omer Durak, Jeffrey D. Macklis   +2 more
doaj   +1 more source

Specific frontal neural dynamics contribute to decisions to check

Nature Communications, 2016
Information seeking is thought to rely on the brain's frontal cortex but which regions specifically control this drive remains unknown. Here the authors show that monkeys deciding to seek information on the current state of the environment showed ...
Frederic M. Stoll, Vincent Fontanier, Emmanuel Procyk   +2 more
doaj   +1 more source

Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury

Stem Cell Research & Therapy, 2020
Background Retinal and/or optic nerve injury is one of the leading causes of blindness due to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress this neurodegeneration.
Seyedeh-Zahra Seyedrazizadeh, Sara Poosti, Abdoreza Nazari, Mehdi Alikhani, Faezeh Shekari, Farzad Pakdel, Koorosh Shahpasand, Leila Satarian, Hossein Baharvand   +8 more
doaj   +1 more source

Enhanced cultivation of chicken primordial germ cells

Scientific Reports, 2023
The cultivation and expansion of chicken primordial germ cells (cPGCs) are of critical importance for both biotechnological applications and the management of poultry genetic biodiversity.
Nima Dehdilani, Sara Yousefi Taemeh, Sylvie Rival-Gervier, Guillaume Montillet, Clémence Kress, Christian Jean, Lena Goshayeshi, Hesam Dehghani, Bertrand Pain   +8 more
doaj   +1 more source

NMDAR mediated dynamic changes in m6A inversely correlates with neuronal translation

Scientific Reports, 2022
Epitranscriptome modifications are crucial in translation regulation and essential for maintaining cellular homeostasis. N6 methyladenosine (m6A) is one of the most abundant and well-conserved epitranscriptome modifications, which is known to play a ...
Naveen Kumar Chandappa Gowda, Bharti Nawalpuri, Sarayu Ramakrishna, Vishwaja Jhaveri, Ravi S. Muddashetty   +4 more
doaj   +1 more source

Locally induced neural stem cells/pluripotent stem cells for in vivo cell replacement therapy [PDF]

, 2008
: Neural stem cells hold the key to innovative new treatments for age-associated degeneration and traumatic injury to the brain and spinal cord. We hypothesized that the in vivo induced pluripotent stem cells or neural stem cells through 'forced gene ...
Arias-Carrión, O, Yuan, TF
core   +3 more sources