Results 81 to 90 of about 1,057,184 (299)

Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy. [PDF]

, 2019
Glioma is one of the most refractory types of brain tumor. Accurate tumor boundary identification and complete resection of the tumor are essential for glioma removal during brain surgery.
Alfano, Robert R, Cheng, Gangge, Liu, Cheng-Hui, Shi, Lingyan, Wang, Kai, Wu, Binlin, Yu, Xinguang, Zhang, Chunyuan, Zhang, Lin, Zhao, Mingyue, Zhou, Yan, Zhu, Ke, Zong, Rui   +12 more
core   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

From Patient-Specific Mathematical Neuro-Oncology to Precision Medicine

Frontiers in Oncology, 2013
Gliomas are notoriously aggressive, malignant brain tumors that have variable response to treatment. These patients often have poor prognosis, informed primarily by histopathology.
Anne eBaldock, Anne eBaldock, Russell eRockne, Russell eRockne, Addie eBoone, Maxwell eNeal, Maxwell eNeal, Carly eBridge, Carly eBridge, Laura eGuyman, Laura eGuyman, Maceij eMrugala, Jason eRockhill, Kristin Rae Swanson, Kristin Rae Swanson, Kristin Rae Swanson, Andrew Daniel Trister, A eHawkins-Daarud, A eHawkins-Daarud, David M Corwin, David M Corwin   +20 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Optimized culturing yields high success rates and preserves molecular heterogeneity, enabling personalized screening for high-grade gliomas

npj Precision Oncology
To discover new treatment options for high-grade glioma (HGG), robust in vitro models are essential, but reliably establishing patient-derived cell cultures remains challenging. We established glioma stem-like cell (GSC) cultures from 114 consecutive HGG
Cassandra Posthoorn-Verheul, Federica Fabro, Ioannis Ntafoulis, Chelsea den Hollander, Iris S. C. Verploegh, Rutger Balvers, Trisha V. Kers, Jessica Hoogeveen, Judith van der Burg, Bert Eussen, Annelies de Klein, Kate J. Feller, Miao-Ping Chien, Clemens M. F. Dirven, Sieger Leenstra, Martine L. M. Lamfers   +15 more
doaj   +1 more source

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]

, 2010
Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad, Castresana, Javier S, Eberhart, Charles G., Fan, Xing, Rey, Juan A, Shahi, Mehdi H, Sinha, Subrata   +6 more
core   +5 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Expanded specific T cells to hypomutated regions of the SARS-CoV-2 using mRNA electroporated antigen-presenting cells

Molecular Therapy: Methods & Clinical Development
The COVID-19 pandemic has caused about seven million deaths worldwide. Preventative vaccines have been developed including Spike gp mRNA-based vaccines that provide protection to immunocompetent patients. However, patients with primary immunodeficiencies,
Elizabeth Ogando-Rivas, Paul Castillo, Changlin Yang, Vrunda Trivedi, Dingpeng Zhang, Fernanda Pohl-Guimarães, Ruixuan Liu, Arnav Barpujari, Kate M. Candelario, Hector Mendez-Gomez, Elias J. Sayour, Duane A. Mitchell   +11 more
doaj   +1 more source

The role of the immune system in brain metastasis [PDF]

, 2019
Metastatic brain tumors are the most common brain tumors in adults. With numerous successful advancements in systemic treatment of most common cancer types, brain metastasis is becoming increasingly important in the overall prognosis of cancer patients ...
Dey, Mahua, Leibold, Adam T., Monaco, Gina N.   +2 more
core