Results 61 to 70 of about 214,971 (307)

Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats

Frontiers in Pharmacology
IntroductionThe interplay between opioid analgesics and sepsis in intensive care units (ICUs) is multifaceted, often amplifying immune dysregulation and adversely affecting cardiovascular outcomes.AimWe investigated whether morphine, the prototypical ...
Mohamed Abdelnaby, Marwa Y. Sallam, Mai M. Helmy, Hanan M. El-Gowelli, Muddanna S. Rao, Mahmoud M. El-Mas, Mahmoud M. El-Mas   +6 more
doaj   +1 more source

A Review of the Pedunculopontine Nucleus in Parkinson's Disease

Frontiers in Aging Neuroscience, 2018
The pedunculopontine nucleus (PPN) is situated in the upper pons in the dorsolateral portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear nucleus level, and is part of the mesenphalic locomotor region (MLR) in the ...
Isobel T. French, Kalai A. Muthusamy
doaj   +1 more source

Putative Role of the Lung–Brain Axis in the Pathogenesis of COVID-19-Associated Respiratory Failure: A Systematic Review

Biomedicines, 2022
The emergence of SARS-CoV-2 and its related disease caused by coronavirus (COVID-19) has posed a huge threat to the global population, with millions of deaths and the creation of enormous social and healthcare pressure.
Francesco Gentile, Tommaso Bocci, Silvia Coppola, Tommaso Pozzi, Leo Modafferi, Alberto Priori, Davide Chiumello   +6 more
doaj   +1 more source

The Mammalian Interaural Time Difference Detection Circuit Is Differentially Controlled by GABAB Receptors during Development [PDF]

, 2010
Throughout development GABAB receptors (GABABRs) are widely expressed in the mammalian brain. In mature auditory brainstem neurons, GABABRs are involved in the short-term regulation of the strength and dynamics of excitatory and inhibitory inputs, thus ...
Grothe, Benedikt, B. Grothe, U. Koch, Hassfurth, Benjamin, B. Hassfurth, Koch, Ursula   +5 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Pathophysiology and Etiology of Brainstem-Related Dysphagia

Audiology Research
Background: Brainstem-related dysphagia represents a complex and severe form of neurogenic dysphagia (ND) arising from lesions that disrupt the central pattern generator (CPG) for swallowing located in the medulla oblongata.
Lucia D’Alatri, Maria Raffaella Marchese, Angelo Tizio, Jacopo Galli   +3 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Intra brainstem connectivity is impaired in chronic fatigue syndrome

, 2019
In myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), abnormal MRI correlations with symptom severity and autonomic measures have suggested impaired nerve signal conduction within the brainstem.
Barnden, LR, Staines, DR, Finegan, K, Shan, ZY, Marshall-Gradisnik, S, Ireland, T, Bhuta, S   +6 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Linking actions to outcomes : the role of the posterior pedunculopontine tegmental nucleus in instrumental learning [PDF]

, 2012
Located in the mesopontine tegmentum, the pedunculopontine tegmental nucleus (PPTg) is comprised principally of glutamatergic, cholinergic and GABAergic neurons.
MacLaren, Duncan A. A.
core   +2 more sources