Results 51 to 60 of about 166,117 (229)
Advanced Science, EarlyView.As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia +13 more
wiley +1 more source
SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer
Advanced Science, EarlyView.Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian +8 more
wiley +1 more source
An optimization study of a multiple-row pin-vented brake disc to promote brake cooling using computational fluid dynamics [PDF]
, 2009 Brake disc cooling is an important area of research for high-performance brake disc manufacturers, users as well as academia. In high-demand braking applications, vented discs are increasingly being used as these are considered to have high heat ...
Palmer, E. +5 more
core +1 more source
Brake Disk Modal Analysis for Suspended Monorail Vehicle
机车电传动, 2016 Vibration during disk brake process will generate brake noise and uneven contacting between brake pad and brake disk, so it is important for analysis the whole disk brake system’s performance to research the vibration characteristics of the brake disk ...
Xu Yan, Wang Yueming
doaj
Materials Research Express, 2019 The idealization of this research work is to extend the utilization of the naturally available fibers as a key ingredient in the development of a non-asbestos free brake pad.
G Sai Krishnan +4 more
doaj +1 more source
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source
BMEMat, EarlyView.This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li +9 more
wiley +1 more source
Topology Analysis of Bicycle Rim Brake Pad to Improve Braking Performance
MATEC Web of Conferences, 2018 Various parameters of rubber brake pad tribology will affect the braking performance of a rim brake system of a bicycle. Out of those, three main parameters are contact length of brake pad, surface topology of friction surface, and the thickness of rim ...
Keong Le-Onn, Teoh Choe-Yung
doaj +1 more source
Fueling Tomorrow: Scenario Planning for the Future of Gas Stations
Business Strategy and the Environment, EarlyView.ABSTRACT Transport electrification is reshaping the service infrastructures that mediate everyday mobility, yet most electrification scenario studies remain macrolevel and offer limited insight into how incumbent forecourt (gas‐station) networks can adapt under deep uncertainty.
Joao Gabriel Rosa +2 more
wiley +1 more source
Modeling the Friction Boundary Layer of an Entire Brake Pad with an Abstract Cellular Automaton
Lubricants, 2018 The principle energy exchange of a brake system occurs in the tribological boundary layer between the pad and the disc. The associated phenomena are primarily responsible for the dynamics of brake systems.
Georg-Peter Ostermeyer +1 more
doaj +1 more source