Results 111 to 120 of about 458,685 (318)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

BUILDING TOURISM DESTINATION BRAND FROM THE RELATIONAL VIEW PERSPECTIVE: THE ITALIAN PROJECT “RETE DESTINAZIONE SUD”

open access: yesEnlightening Tourism: A Pathmaking Journal, 2018
The paper deals with a case study regarding an Italian tourism project analyzed through the lens of a multiple perspectives framework based on Relational View (RV), Stakeholder Engagement (SE), and Value Co-creation (VCc).
Marco Pellicano   +4 more
doaj   +1 more source

Brand molecule theory: An exploratory study of a telecommunication company’s events [PDF]

open access: yes
Over the past decade or so, events have become key elements in strategic marketing initiatives with event marketing or, as it is sometimes known, live or experiential marketing, dominating some promotional budgets.
Fox, Dorothy, Goodwin, Aimee
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The effect of gamification on brand co-creation in app-based businesses: investigating the mediating role of consumer engagement and the moderating role of hedonic and innovativeness [PDF]

open access: yesارزش آفرینی در مدیریت کسب و کار
Today, customer participation in branding through brand co-creation behavior is one of the most important concerns and challenges of industries in this field.
Rayhane Rezagholizade   +2 more
doaj   +1 more source

FairShares Model [PDF]

open access: yes, 2013
The attached document provides an introduction to the FairShares Model, a new brand and concept for self-governing social enterprises operating under Company and Co operative ...
Dickins, Nicci   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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