Results 71 to 80 of about 18,240 (315)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

A Marketer’s Point of Views: Strategy of Developing and Reinforcing Brand Loyalty In The 1990’s

open access: yesJurnal Siasat Bisnis, 2009
The rapid change in competition and technology results in decrease in brand loyalty and business decline. This means that keeping customer loyalty is a very challenging effort today because brand loyalty is very important to acquire, maintain, and ...
Anas Hidayat
doaj   +4 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

PENGARUH BRAND IMAGE DAN BRAND TRUST TERHADAP BRAND LOYALTY TEH BOTOL SOSRO Survei Konsumen Teh Botol Sosro di Food Court ITC Cempaka Mas, Jakarta timur

open access: yesJurnal Riset Manajemen Sains Indonesia, 2012
The purposes of this research are: 1) To know the description of brand image and brand trust and the influence of them towards brand loyalty of Teh Botol Sosro. 2) To test empirically the influence of brand image towards brand loyalty of Teh Botol Sosro.
Mohammad Rizan   +2 more
doaj  

Exploring the influence of ‘Korean Wave’ on brand loyalty: The moderating role of product type

open access: yesAsian Management and Business Review
The ‘Korean Wave’ has significantly impacted the global economy, especially in Indonesia. However, there is a gap in understanding how Korean celebrities, as brand ambassadors, influence local consumer behavior and purchase intentions.
Lady Lady   +3 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

The impact of packaging, price and brand awareness on brand loyalty: Evidence from the paint retailing industry

open access: yesActa Commercii, 2014
Purpose: The purpose of the study was to investigate the impact of packaging, price and brand awareness on brand loyalty. Rationale: The study sought to extend empirical evidence on the association between brand loyalty and product-related factors ...
Manilall Dhurup   +2 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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