Results 1 to 10 of about 49,034 (223)

Surgical menopause in patients with BRCA mutation, the role of hormone therapy

Revista del Hospital Italiano de Buenos Aires, 2023
Introduction: Women with BRCA1/2 (mBRCA) mutation have an increased risk of developing breast (BC) and ovarian (OC) cancer. Bilateral salpingo-oophorectomy (BOS) is associated with an 80% risk reduction for OC and 50% for BC. The recommended age for this
María Alejandra Belardo, Magali L. Galarza Taborda   +1 more
doaj   +1 more source

Primary multiple BRCA associated breast cancer and ovarian cancer (clinical case)

Медицинский совет, 2020
Introduction. The study of mutation in BRCA1/2 genes was first initiated in the USA and Europe, and later in Russia. Statistics indicate that women with the BRCA1/BRCA2 mutation have a higher risk of breast and/or ovarian cancer than the general ...
I. B. Kononenko, A. V. Snegovoy, Y. A. Bozhchenko, D. N. Kravchenko, Vladimir Yu. Selchuk, O. V. Palchinskaia   +5 more
doaj   +1 more source

Overall survival analysis of > 65-year-old patients with breast cancer based on their molecular, clinicopathological and laboratory factors

Archives of Medical Science, 2022
Introduction The objective of the present study was to characterize > 65-year-old patients with breast cancer according to clinicopathological, molecular and laboratory factors.
Joanna Huszno, Zofia Kolosza, Jolanta Mrochem -Kwarciak, Ewa Grzybowska   +3 more
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Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

Cancer Biology & Medicine, 2023
Objective: The choice of chemotherapeutic regimen for triple-negative breast cancer (TNBC) remains controversial. Homologous recombination deficiency (HRD) has attracted increasing attention in informing chemotherapy treatment.
Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu, Peng Yuan   +10 more
doaj   +1 more source

Acquired Treatment Resistance in a Patient with Metastatic PD-L1-Positive Breast Cancer and Germline BRCA1 Mutation

Case Reports in Oncology, 2023
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with higher rates of relapse and mortality compared to other subtypes. Chemotherapy has been a mainstream treatment approach for TNBC due to the lack of therapeutic
Toko Kumeta, Kei Yamaguchi, Ryosuke Hayami, Kazumori Arai, Michiko Tsuneizumi, Ryoichi Matsunuma   +5 more
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REPEATED OPTIMAL CYTOREDUCTIVE SURGERIES IN COMBINED MODALITY TREATMENT OF OVARIAN CANCER. CASE REPORT

Сибирский онкологический журнал, 2017
To date, the algorithm for the treatment of recurrent ovarian cancer and the criteria for selecting patients for performing secondary cytoreductive surgeries have not been fully developed.
S. V. Molchanov, L. A. Kolomiets, O. V. Shpilyeva   +2 more
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Modern interpretation of risk factors in breast cancer of women

Journal of Mind and Medical Sciences, 2022
Breast cancer is a major public health problem, being the most common cancer diagnosed in women and accounting for more than 1 in 10 new diagnoses of cancer each year.
Oana Denisa Bălălău, Răzvan Valentin Scăunașu, Octavian Gabriel Olaru, Anca Silvia Dumitriu, Stana Paunica, Liliana Florina Andronache, Anca Daniela Stănescu   +6 more
doaj   +1 more source

Triple-negative breast cancer arising in a fibroadenoma in BRCA 1 mutated patient

Journal of Medical Ultrasound, 2023
We describe the case of a 35-year-old woman who comes to our institute with a palpable lump on her left breast. Clinically the mass was mobile, nontender and with no nipple discharge. Sonography revealed a circumscribed, oval-shaped, and hypoechoic mass,
Nicole Brunetti, Irene Valente, Francesca Pitto, Massimo Calabrese   +3 more
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Excellent Response to Olaparib in a Patient with Metastatic Pancreatic Adenocarcinoma with Germline BRCA1 Mutation after Progression on FOLFIRINOX: Case Report and Literature Review

Case Reports in Oncology, 2020
Metastatic pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Until recently, cytotoxic chemotherapy was the only treatment option. Currently, there are subgroups of patients with PDAC either with somatic or germline mutations who are ...
Jefferson Rios Pimenta, Serli Kiyomi Nakao Ueda, Renata D’Alpino Peixoto   +2 more
doaj   +1 more source

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

Cell Reports, 2015
Resolution of DNA double-strand breaks (DSBs) is essential for the suppression of genome instability. DSB repair in transcriptionally active genomic regions represents a unique challenge that is associated with ataxia telangiectasia mutated (ATM) kinase ...
Shane M. Harding, Jonathan A. Boiarsky, Roger A. Greenberg   +2 more
doaj   +1 more source